{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/36850"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/36850","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease","abstract":"Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein biomarkers of PD have concentrated on analyzing cerebrospinal fluid (CSF). Although CSF is ideal due to its intimate relationship with cells of the central nervous system, obtaining it is relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and phosphorylated tau181 (p-tau181) EVs are present in PD plasma when compared to plasma from HCs. Further research is needed to determine if correlation exists between EV concentration and clinically determined values.","abstract_html":"Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein biomarkers of PD have concentrated on analyzing cerebrospinal fluid (CSF). Although CSF is ideal due to its intimate relationship with cells of the central nervous system, obtaining it is relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and phosphorylated tau181 (p-tau181) EVs are present in PD plasma when compared to plasma from HCs. Further research is needed to determine if correlation exists between EV concentration and clinically determined values.","abstract_has_math":false,"creators":["Flondra, Kaitlyn M"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Anatomy and Cell Biology","degree_department":null,"school":null,"contributors":[],"advisors":["Whitehead, Shawn N.","Pasternak, Stephen"],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-06-12","date_published":"2023-06-12","updated_at":"2026-07-27T21:56:11Z","subjects":["Parkinson's disease","Biomarker","Extracellular vesicle","Nanoflow cytometry"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/36850","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Whitehead, Shawn N.","Pasternak, Stephen"]},{"key":"dc:creator","label":"Author","values":["Flondra, Kaitlyn M"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:26:31Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:26:31Z"]},{"key":"dc:date.issued","label":"Date","values":["2023-06-12"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Anatomy and Cell Biology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Parkinson's disease","Biomarker","Extracellular vesicle","Nanoflow cytometry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/36850"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein biomarkers of PD have concentrated on analyzing cerebrospinal fluid (CSF). Although CSF is ideal due to its intimate relationship with cells of the central nervous system, obtaining it is relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and phosphorylated tau181 (p-tau181) EVs are present in PD plasma when compared to plasma from HCs. Further research is needed to determine if correlation exists between EV concentration and clinically determined values."]},{"key":"dc:title","label":"Title","values":["Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Whitehead, Shawn N.","Pasternak, Stephen"],"dc:creator":["Flondra, Kaitlyn M"],"dc:date.accessioned":["2025-07-10T21:26:31Z"],"dc:date.available":["2025-07-10T21:26:31Z"],"dc:date.issued":["2023-06-12"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Parkinson’s Disease (PD) is a common neurodegenerative disease that is projected to increase in prevalence with the aging population. Current diagnosis of PD is based on clinical criteria as there exists no objective biomarker capable of diagnosing the disease. Clinical trials into protein biomarkers of PD have concentrated on analyzing cerebrospinal fluid (CSF). Although CSF is ideal due to its intimate relationship with cells of the central nervous system, obtaining it is relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and phosphorylated tau181 (p-tau181) EVs are present in PD plasma when compared to plasma from HCs. Further research is needed to determine if correlation exists between EV concentration and clinically determined values."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/36850"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Parkinson's disease","Biomarker","Extracellular vesicle","Nanoflow cytometry"],"dc:title":["Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease"],"dc:type":["thesis"],"thesis:degree_discipline":["Anatomy and Cell Biology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:11Z"}