{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/36563"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/36563","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"The effects of acute high- and low-intensity exercise on Hsp70 and Hsp90 accumulation in rat skeletal myofibres and vasculature","abstract":"Exercise induces cytoprotective stress proteins in blood vessels (BV) and skeletal myofibres. The localization and extent of induction with different exercise intensities is unclear. Rats (n=10 per group) were run at high (HIEX; 30m/min) versus low-intensity exercise (LOEX; 15m/min) for 1hr, sacrificed 24hr later. Sections of the white portion of the vastus were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs expressing Hsp70 would express Hsp70. Ratio of BVs with Hsp70/total vessels and Hsp70 density was greater in HIEX versus LOEX (p","abstract_html":"Exercise induces cytoprotective stress proteins in blood vessels (BV) and skeletal myofibres. The localization and extent of induction with different exercise intensities is unclear. Rats (n=10 per group) were run at high (HIEX; 30m/min) versus low-intensity exercise (LOEX; 15m/min) for 1hr, sacrificed 24hr later. Sections of the white portion of the vastus were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs expressing Hsp70 would express Hsp70. Ratio of BVs with Hsp70/total vessels and Hsp70 density was greater in HIEX versus LOEX (p","abstract_has_math":false,"creators":["Kowalchuk, Hana"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":[],"advisors":["Earl Noble"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-28","date_published":"2013-08-28","updated_at":"2026-07-27T21:56:11Z","subjects":["Heat Shock Protein","Hsp70","Hsp90","vasculature","skeletal myofibre","intensity-dependent","immunofluorescence"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/36563","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Earl Noble"]},{"key":"dc:creator","label":"Author","values":["Kowalchuk, Hana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:23:17Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:23:17Z"]},{"key":"dc:date.issued","label":"Date","values":["2013-08-28"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Heat Shock Protein","Hsp70","Hsp90","vasculature","skeletal myofibre","intensity-dependent","immunofluorescence"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/36563"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Exercise induces cytoprotective stress proteins in blood vessels (BV) and skeletal myofibres. The localization and extent of induction with different exercise intensities is unclear. Rats (n=10 per group) were run at high (HIEX; 30m/min) versus low-intensity exercise (LOEX; 15m/min) for 1hr, sacrificed 24hr later. Sections of the white portion of the vastus were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs expressing Hsp70 would express Hsp70. Ratio of BVs with Hsp70/total vessels and Hsp70 density was greater in HIEX versus LOEX (p"]},{"key":"dc:title","label":"Title","values":["The effects of acute high- and low-intensity exercise on Hsp70 and Hsp90 accumulation in rat skeletal myofibres and vasculature"]}]}],"canonical_facts":{"dc:contributor.advisor":["Earl Noble"],"dc:creator":["Kowalchuk, Hana"],"dc:date.accessioned":["2025-07-10T21:23:17Z"],"dc:date.available":["2025-07-10T21:23:17Z"],"dc:date.issued":["2013-08-28"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Exercise induces cytoprotective stress proteins in blood vessels (BV) and skeletal myofibres. The localization and extent of induction with different exercise intensities is unclear. Rats (n=10 per group) were run at high (HIEX; 30m/min) versus low-intensity exercise (LOEX; 15m/min) for 1hr, sacrificed 24hr later. Sections of the white portion of the vastus were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs expressing Hsp70 would express Hsp70. Ratio of BVs with Hsp70/total vessels and Hsp70 density was greater in HIEX versus LOEX (p"],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/36563"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Heat Shock Protein","Hsp70","Hsp90","vasculature","skeletal myofibre","intensity-dependent","immunofluorescence"],"dc:title":["The effects of acute high- and low-intensity exercise on Hsp70 and Hsp90 accumulation in rat skeletal myofibres and vasculature"],"dc:type":["thesis"],"thesis:degree_discipline":["Kinesiology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:11Z"}