{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/34715"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/34715","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease","abstract":"Sensitive and translational tasks that efficiently and accurately assess cognitive function during pre-clinical trials would be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate high-level cognitive and executive functions in mice. This face validity provides the best chance of successful cognitive translation across species. In our study, donepezil had minor effects on the performance of 5xFAD mice in the 5-CSRTT, a touchscreen task evaluating attention. Additionally, 5xFAD mice do not demonstrate impairments in the PVD task, which assesses visual discrimination/ cognitive flexibility. However, the parameters recorded by the touchscreen apparatus found latency differences in task response and reward collection – which led us to uncover severe gait impairments in old 5xFAD mice. In summary, our findings suggest that the 5xFAD mouse model can be used as an animal model of non-cognitive function in AD.","abstract_html":"Sensitive and translational tasks that efficiently and accurately assess cognitive function during pre-clinical trials would be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate high-level cognitive and executive functions in mice. This face validity provides the best chance of successful cognitive translation across species. In our study, donepezil had minor effects on the performance of 5xFAD mice in the 5-CSRTT, a touchscreen task evaluating attention. Additionally, 5xFAD mice do not demonstrate impairments in the PVD task, which assesses visual discrimination/ cognitive flexibility. However, the parameters recorded by the touchscreen apparatus found latency differences in task response and reward collection – which led us to uncover severe gait impairments in old 5xFAD mice. In summary, our findings suggest that the 5xFAD mouse model can be used as an animal model of non-cognitive function in AD.","abstract_has_math":false,"creators":["Lee, Wai-Jane V"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":[],"advisors":["Marco Prado","Vania Prado"],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-06-16","date_published":"2017-06-16","updated_at":"2026-07-27T21:56:18Z","subjects":["Alzheimer's Disease","5xFAD","Visual Discrimination and Cognitive Flexibility","Attention","Gait","Donepezil"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/34715","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Marco Prado","Vania Prado"]},{"key":"dc:creator","label":"Author","values":["Lee, Wai-Jane V"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T20:09:13Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T20:09:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2017-06-16"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Alzheimer's Disease","5xFAD","Visual Discrimination and Cognitive Flexibility","Attention","Gait","Donepezil"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/34715"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Sensitive and translational tasks that efficiently and accurately assess cognitive function during pre-clinical trials would be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate high-level cognitive and executive functions in mice. This face validity provides the best chance of successful cognitive translation across species. In our study, donepezil had minor effects on the performance of 5xFAD mice in the 5-CSRTT, a touchscreen task evaluating attention. Additionally, 5xFAD mice do not demonstrate impairments in the PVD task, which assesses visual discrimination/ cognitive flexibility. However, the parameters recorded by the touchscreen apparatus found latency differences in task response and reward collection – which led us to uncover severe gait impairments in old 5xFAD mice. In summary, our findings suggest that the 5xFAD mouse model can be used as an animal model of non-cognitive function in AD."]},{"key":"dc:title","label":"Title","values":["Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Marco Prado","Vania Prado"],"dc:creator":["Lee, Wai-Jane V"],"dc:date.accessioned":["2025-07-10T20:09:13Z"],"dc:date.available":["2025-07-10T20:09:13Z"],"dc:date.issued":["2017-06-16"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Sensitive and translational tasks that efficiently and accurately assess cognitive function during pre-clinical trials would be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate high-level cognitive and executive functions in mice. This face validity provides the best chance of successful cognitive translation across species. In our study, donepezil had minor effects on the performance of 5xFAD mice in the 5-CSRTT, a touchscreen task evaluating attention. Additionally, 5xFAD mice do not demonstrate impairments in the PVD task, which assesses visual discrimination/ cognitive flexibility. However, the parameters recorded by the touchscreen apparatus found latency differences in task response and reward collection – which led us to uncover severe gait impairments in old 5xFAD mice. In summary, our findings suggest that the 5xFAD mouse model can be used as an animal model of non-cognitive function in AD."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/34715"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Alzheimer's Disease","5xFAD","Visual Discrimination and Cognitive Flexibility","Attention","Gait","Donepezil"],"dc:title":["Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease"],"dc:type":["thesis"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:18Z"}