{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/32349"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/32349","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Investigating Cadm2 genetic variation in attention and motivation","abstract":"CADM2 is a synaptic adhesion molecule associated with cognition and impulsivity. It is primarily expressed in the brain, especially in regions involved in executive function, addiction, motivation, and impulsivity control. Previous genetic studies have associated the CADM2 gene with different attentional and impulsivity traits. Continuous Performance Tests (CPT) are used to assess deficits in attentional function and impulse control in humans. This test has been used to study these deficits in different neuropsychiatric disorders such as ADHD. In the current study, we conducted the rodent version of CPT (rCPT) using touchscreen chambers. Our cohort of wildtype, heterozygous and knock-out Cadm2 mice were run on rCPT and a Progressive Ratio task to investigate how the impulsive and motivation related behaviours of these animals may differ. We discovered that Cadm2 genetic variation resulted in differences in these traits, with knock-out animals showing different outcomes compared to the wildtype and heterozygous mice.","abstract_html":"CADM2 is a synaptic adhesion molecule associated with cognition and impulsivity. It is primarily expressed in the brain, especially in regions involved in executive function, addiction, motivation, and impulsivity control. Previous genetic studies have associated the CADM2 gene with different attentional and impulsivity traits. Continuous Performance Tests (CPT) are used to assess deficits in attentional function and impulse control in humans. This test has been used to study these deficits in different neuropsychiatric disorders such as ADHD. In the current study, we conducted the rodent version of CPT (rCPT) using touchscreen chambers. Our cohort of wildtype, heterozygous and knock-out Cadm2 mice were run on rCPT and a Progressive Ratio task to investigate how the impulsive and motivation related behaviours of these animals may differ. We discovered that Cadm2 genetic variation resulted in differences in these traits, with knock-out animals showing different outcomes compared to the wildtype and heterozygous mice.","abstract_has_math":false,"creators":["Choi, Esther Y"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":[],"advisors":["Khokhar, Jibran Y."],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-04-22","date_published":"2025-04-22","updated_at":"2026-07-27T21:56:03Z","subjects":["CADM2","Rodent Continuous Performance Task","Progressive Ratio","Impulsivity","Attention","Motivation"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/32349","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Khokhar, Jibran Y."]},{"key":"dc:creator","label":"Author","values":["Choi, Esther Y"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T19:29:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T19:29:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-04-22"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["CADM2","Rodent Continuous Performance Task","Progressive Ratio","Impulsivity","Attention","Motivation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/32349"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["CADM2 is a synaptic adhesion molecule associated with cognition and impulsivity. It is primarily expressed in the brain, especially in regions involved in executive function, addiction, motivation, and impulsivity control. Previous genetic studies have associated the CADM2 gene with different attentional and impulsivity traits. Continuous Performance Tests (CPT) are used to assess deficits in attentional function and impulse control in humans. This test has been used to study these deficits in different neuropsychiatric disorders such as ADHD. In the current study, we conducted the rodent version of CPT (rCPT) using touchscreen chambers. Our cohort of wildtype, heterozygous and knock-out Cadm2 mice were run on rCPT and a Progressive Ratio task to investigate how the impulsive and motivation related behaviours of these animals may differ. We discovered that Cadm2 genetic variation resulted in differences in these traits, with knock-out animals showing different outcomes compared to the wildtype and heterozygous mice."]},{"key":"dc:title","label":"Title","values":["Investigating Cadm2 genetic variation in attention and motivation"]}]}],"canonical_facts":{"dc:contributor.advisor":["Khokhar, Jibran Y."],"dc:creator":["Choi, Esther Y"],"dc:date.accessioned":["2025-07-10T19:29:30Z"],"dc:date.available":["2025-07-10T19:29:30Z"],"dc:date.issued":["2025-04-22"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["CADM2 is a synaptic adhesion molecule associated with cognition and impulsivity. It is primarily expressed in the brain, especially in regions involved in executive function, addiction, motivation, and impulsivity control. Previous genetic studies have associated the CADM2 gene with different attentional and impulsivity traits. Continuous Performance Tests (CPT) are used to assess deficits in attentional function and impulse control in humans. This test has been used to study these deficits in different neuropsychiatric disorders such as ADHD. In the current study, we conducted the rodent version of CPT (rCPT) using touchscreen chambers. Our cohort of wildtype, heterozygous and knock-out Cadm2 mice were run on rCPT and a Progressive Ratio task to investigate how the impulsive and motivation related behaviours of these animals may differ. We discovered that Cadm2 genetic variation resulted in differences in these traits, with knock-out animals showing different outcomes compared to the wildtype and heterozygous mice."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/32349"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["CADM2","Rodent Continuous Performance Task","Progressive Ratio","Impulsivity","Attention","Motivation"],"dc:title":["Investigating Cadm2 genetic variation in attention and motivation"],"dc:type":["thesis"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:03Z"}