A Composite Material-based Computational Model for Diaphragm Muscle Biomechanical Simulation

Lung cancer is the most common cause of cancer related death among both men and women. Radiation therapy is the most widely used treatment for this disease. Motion compensation for tumor movement is often clinically important and biomechanics-based motion models may provide the most robust method as they are based on the physics of motion. In this study, we aim to develop a patient specific biomechanical model that predicts the deformation field of the diaphragm muscle during respiration. The first part of the project involved developing an accurate and adaptable micro-to-macro mechanical approach for skeletal muscle tissue modelling for application in a FE solver. The next objective was to develop the FE-based mechanical model of the diaphragm muscle based on patient specific 4D-CT data. The model shows adaptability to pathologies and may have the potential to be incorporated into respiratory models for the aid in treatment and diagnosis of diseases.

Name thesis:degree_name

M Eng Sci

Discipline thesis:degree_discipline

Biomedical Engineering

Grantor dc:publisher

The University of Western Ontario

Year dc:date.issued

2018

Author dc:creator

• Coelho, Brett

Advisor dc:contributor.advisor

• Samani, Abbas

• Lung cancer
• Bio-mechanical modelling
• Diaphragm Muscle

Language dc:language.iso

en_ca

Handle dc:identifier.uri

https://hdl.handle.net/20.500.14721/31312

OAI identifier oai:identifier

oai:uwo.scholaris.ca:20.500.14721/31312