{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/29432"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/29432","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Neural Regions Affecting Female Aggression and Receptivity in Drosophila melanogaster","abstract":"The genetic tools that exist in Drosophila melanogaster make it possible to assess the influence of specific regions of the brain on complex behaviour. Examples of such behaviours include female aggression and receptivity to male courtship. Silencing a candidate region called the mushroom body (MB) was found to decrease female receptivity. Additionally, silencing a specific subset of the MB, the alpha/beta lobes, was also found to decrease receptivity. SIFamide neurons are known to effect receptivity, though manipulation of SIFamide signaling in the MB produced no such changes in receptivity. Aggression, another complex behaviour in Drosophila, was also affected by genetically controlled neural manipulation. More specifically, hyperactivation of a subset of neurons expressing the doublesex gene was found to incite high amounts of aggression in females but not males. Furthermore, the aggression demonstrated by these females differed based on the stimulus presented by the partners, with locomotion being a major elicitor of aggression.","abstract_html":"The genetic tools that exist in Drosophila melanogaster make it possible to assess the influence of specific regions of the brain on complex behaviour. Examples of such behaviours include female aggression and receptivity to male courtship. Silencing a candidate region called the mushroom body (MB) was found to decrease female receptivity. Additionally, silencing a specific subset of the MB, the alpha/beta lobes, was also found to decrease receptivity. SIFamide neurons are known to effect receptivity, though manipulation of SIFamide signaling in the MB produced no such changes in receptivity. Aggression, another complex behaviour in Drosophila, was also affected by genetically controlled neural manipulation. More specifically, hyperactivation of a subset of neurons expressing the doublesex gene was found to incite high amounts of aggression in females but not males. Furthermore, the aggression demonstrated by these females differed based on the stimulus presented by the partners, with locomotion being a major elicitor of aggression.","abstract_has_math":false,"creators":["Charles, Brendan S"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":[],"advisors":["Moehring, Amanda J."],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-08-23","date_published":"2019-08-23","updated_at":"2026-07-27T21:56:05Z","subjects":["Drosophila","female aggression","female receptivity","doublesex","mushroom body","SIFamide"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/29432","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Moehring, Amanda J."]},{"key":"dc:creator","label":"Author","values":["Charles, Brendan S"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T18:31:51Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T18:31:51Z"]},{"key":"dc:date.issued","label":"Date","values":["2019-08-23"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Drosophila","female aggression","female receptivity","doublesex","mushroom body","SIFamide"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/29432"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["The genetic tools that exist in Drosophila melanogaster make it possible to assess the influence of specific regions of the brain on complex behaviour. Examples of such behaviours include female aggression and receptivity to male courtship. Silencing a candidate region called the mushroom body (MB) was found to decrease female receptivity. Additionally, silencing a specific subset of the MB, the alpha/beta lobes, was also found to decrease receptivity. SIFamide neurons are known to effect receptivity, though manipulation of SIFamide signaling in the MB produced no such changes in receptivity. Aggression, another complex behaviour in Drosophila, was also affected by genetically controlled neural manipulation. More specifically, hyperactivation of a subset of neurons expressing the doublesex gene was found to incite high amounts of aggression in females but not males. Furthermore, the aggression demonstrated by these females differed based on the stimulus presented by the partners, with locomotion being a major elicitor of aggression."]},{"key":"dc:title","label":"Title","values":["Neural Regions Affecting Female Aggression and Receptivity in Drosophila melanogaster"]}]}],"canonical_facts":{"dc:contributor.advisor":["Moehring, Amanda J."],"dc:creator":["Charles, Brendan S"],"dc:date.accessioned":["2025-07-10T18:31:51Z"],"dc:date.available":["2025-07-10T18:31:51Z"],"dc:date.issued":["2019-08-23"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["The genetic tools that exist in Drosophila melanogaster make it possible to assess the influence of specific regions of the brain on complex behaviour. Examples of such behaviours include female aggression and receptivity to male courtship. Silencing a candidate region called the mushroom body (MB) was found to decrease female receptivity. Additionally, silencing a specific subset of the MB, the alpha/beta lobes, was also found to decrease receptivity. SIFamide neurons are known to effect receptivity, though manipulation of SIFamide signaling in the MB produced no such changes in receptivity. Aggression, another complex behaviour in Drosophila, was also affected by genetically controlled neural manipulation. More specifically, hyperactivation of a subset of neurons expressing the doublesex gene was found to incite high amounts of aggression in females but not males. Furthermore, the aggression demonstrated by these females differed based on the stimulus presented by the partners, with locomotion being a major elicitor of aggression."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/29432"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Drosophila","female aggression","female receptivity","doublesex","mushroom body","SIFamide"],"dc:title":["Neural Regions Affecting Female Aggression and Receptivity in Drosophila melanogaster"],"dc:type":["thesis"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:05Z"}