{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/27622"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/27622","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"The role of muscle strength and voluntary activation on symptomatic fatigue in multiple sclerosis","abstract":"This study investigated the role of muscle strength and voluntary activation (VA) on symptomatic fatigue in individuals with multiple sclerosis (MS). Nine women with relapsing- remitting or secondary-progressive MS (mean age, 43yrs) were compared to nine healthy women (mean age, 37yrs). Symptomatic fatigue was assessed using the Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale, and Visual Analogue Fatigue Scale. Functional capacity was assessed with a 6-Minute Walk Test (6-MWT). Muscle strength and VA were determined using twitch interpolation applied to the right dorsiflexor muscles during maximal voluntary isometric contractions (MVIC). Muscle fatigue was assessed during a sustained submaximal contraction. Distance during the 6-MWT, muscle strength and VA were significantly lower in the MS group. MFIS scores were negatively associated with muscle strength and VA. The MS group was more easily fatigued, as measured by MVIC. In conclusion, symptomatic fatigue is associated with muscle fatigue and weakness in individuals with MS.","abstract_html":"This study investigated the role of muscle strength and voluntary activation (VA) on symptomatic fatigue in individuals with multiple sclerosis (MS). Nine women with relapsing- remitting or secondary-progressive MS (mean age, 43yrs) were compared to nine healthy women (mean age, 37yrs). Symptomatic fatigue was assessed using the Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale, and Visual Analogue Fatigue Scale. Functional capacity was assessed with a 6-Minute Walk Test (6-MWT). Muscle strength and VA were determined using twitch interpolation applied to the right dorsiflexor muscles during maximal voluntary isometric contractions (MVIC). Muscle fatigue was assessed during a sustained submaximal contraction. Distance during the 6-MWT, muscle strength and VA were significantly lower in the MS group. MFIS scores were negatively associated with muscle strength and VA. The MS group was more easily fatigued, as measured by MVIC. In conclusion, symptomatic fatigue is associated with muscle fatigue and weakness in individuals with MS.","abstract_has_math":false,"creators":["Davidson, Shannon P"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":[],"advisors":["Timothy J. Doherty"],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-09-29","date_published":"2017-09-29","updated_at":"2026-07-27T21:56:11Z","subjects":[],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/27622","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Timothy J. Doherty"]},{"key":"dc:creator","label":"Author","values":["Davidson, Shannon P"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T15:31:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T15:31:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2017-09-29"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/27622"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["This study investigated the role of muscle strength and voluntary activation (VA) on symptomatic fatigue in individuals with multiple sclerosis (MS). Nine women with relapsing- remitting or secondary-progressive MS (mean age, 43yrs) were compared to nine healthy women (mean age, 37yrs). Symptomatic fatigue was assessed using the Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale, and Visual Analogue Fatigue Scale. Functional capacity was assessed with a 6-Minute Walk Test (6-MWT). Muscle strength and VA were determined using twitch interpolation applied to the right dorsiflexor muscles during maximal voluntary isometric contractions (MVIC). Muscle fatigue was assessed during a sustained submaximal contraction. Distance during the 6-MWT, muscle strength and VA were significantly lower in the MS group. MFIS scores were negatively associated with muscle strength and VA. The MS group was more easily fatigued, as measured by MVIC. In conclusion, symptomatic fatigue is associated with muscle fatigue and weakness in individuals with MS."]},{"key":"dc:title","label":"Title","values":["The role of muscle strength and voluntary activation on symptomatic fatigue in multiple sclerosis"]}]}],"canonical_facts":{"dc:contributor.advisor":["Timothy J. Doherty"],"dc:creator":["Davidson, Shannon P"],"dc:date.accessioned":["2025-07-10T15:31:08Z"],"dc:date.available":["2025-07-10T15:31:08Z"],"dc:date.issued":["2017-09-29"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["This study investigated the role of muscle strength and voluntary activation (VA) on symptomatic fatigue in individuals with multiple sclerosis (MS). Nine women with relapsing- remitting or secondary-progressive MS (mean age, 43yrs) were compared to nine healthy women (mean age, 37yrs). Symptomatic fatigue was assessed using the Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale, and Visual Analogue Fatigue Scale. Functional capacity was assessed with a 6-Minute Walk Test (6-MWT). Muscle strength and VA were determined using twitch interpolation applied to the right dorsiflexor muscles during maximal voluntary isometric contractions (MVIC). Muscle fatigue was assessed during a sustained submaximal contraction. Distance during the 6-MWT, muscle strength and VA were significantly lower in the MS group. MFIS scores were negatively associated with muscle strength and VA. The MS group was more easily fatigued, as measured by MVIC. In conclusion, symptomatic fatigue is associated with muscle fatigue and weakness in individuals with MS."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/27622"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:title":["The role of muscle strength and voluntary activation on symptomatic fatigue in multiple sclerosis"],"dc:type":["thesis"],"thesis:degree_discipline":["Kinesiology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:11Z"}