{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/27370"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/27370","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Poly(ethyl glyoxylate) Solid-Core Particles for Drug Delivery","abstract":"The ability to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the release of cargo. Polymeric nanotechnology containing “self-immolative polymers” looks to alleviate the reliance on high concentrations of stimuli by undergoing complete end-to-end depolymerization via a single stimulus-mediated reaction of an end-cap. Herein, NPs were developed using poly(ethyl glyoxylate) (PEtG) blended with poly(d,l-lactic acid) (PLA) to encapsulate a hydrophobic cargo to be released upon stimulus-triggered cleavage of the PEtG end-cap. The PEtG-PLA NPs were formed using an oil-in-water emulsion-evaporation technique. Particles responsive to stimuli including UV light and reducing conditions were prepared and studied. Cleavage of the end-caps of these polymers was accomplished by introducing the relevant stimuli, resulting in a rapid degradation of the particles and subsequent release of cargo. Nile red as a fluorescent probe and the drug celecoxib were encapsulated within the particles and were shown to be released upon introduction of small amounts of the appropriate stimulus. Initial cell culture studies were performed to investigate the behavior of the systems in vitro. This system provides the ability to tune the responsiveness of the NPs by simply changing the PEtG end-cap, making them a great prospect for stimuli-responsive drug delivery vehicles.","abstract_html":"The ability to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the release of cargo. Polymeric nanotechnology containing “self-immolative polymers” looks to alleviate the reliance on high concentrations of stimuli by undergoing complete end-to-end depolymerization via a single stimulus-mediated reaction of an end-cap. Herein, NPs were developed using poly(ethyl glyoxylate) (PEtG) blended with poly(d,l-lactic acid) (PLA) to encapsulate a hydrophobic cargo to be released upon stimulus-triggered cleavage of the PEtG end-cap. The PEtG-PLA NPs were formed using an oil-in-water emulsion-evaporation technique. Particles responsive to stimuli including UV light and reducing conditions were prepared and studied. Cleavage of the end-caps of these polymers was accomplished by introducing the relevant stimuli, resulting in a rapid degradation of the particles and subsequent release of cargo. Nile red as a fluorescent probe and the drug celecoxib were encapsulated within the particles and were shown to be released upon introduction of small amounts of the appropriate stimulus. Initial cell culture studies were performed to investigate the behavior of the systems in vitro. This system provides the ability to tune the responsiveness of the NPs by simply changing the PEtG end-cap, making them a great prospect for stimuli-responsive drug delivery vehicles.","abstract_has_math":false,"creators":["Gambles, Michael Thomas"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":[],"advisors":["Elizabeth Rachel Gillies"],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-08-14","date_published":"2017-08-14","updated_at":"2026-07-27T21:56:20Z","subjects":["Drug Delivery","Polymer DDS","Polymeric Nanoparticles","Triggerable Release","Self-Immolative Polymer","Stimuli-Responsive","Emulsion-Evaporation"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/27370","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Elizabeth Rachel Gillies"]},{"key":"dc:creator","label":"Author","values":["Gambles, Michael Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T15:29:29Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T15:29:29Z"]},{"key":"dc:date.issued","label":"Date","values":["2017-08-14"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Drug Delivery","Polymer DDS","Polymeric Nanoparticles","Triggerable Release","Self-Immolative Polymer","Stimuli-Responsive","Emulsion-Evaporation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/27370"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["The ability to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the release of cargo. Polymeric nanotechnology containing “self-immolative polymers” looks to alleviate the reliance on high concentrations of stimuli by undergoing complete end-to-end depolymerization via a single stimulus-mediated reaction of an end-cap. Herein, NPs were developed using poly(ethyl glyoxylate) (PEtG) blended with poly(d,l-lactic acid) (PLA) to encapsulate a hydrophobic cargo to be released upon stimulus-triggered cleavage of the PEtG end-cap. The PEtG-PLA NPs were formed using an oil-in-water emulsion-evaporation technique. Particles responsive to stimuli including UV light and reducing conditions were prepared and studied. Cleavage of the end-caps of these polymers was accomplished by introducing the relevant stimuli, resulting in a rapid degradation of the particles and subsequent release of cargo. Nile red as a fluorescent probe and the drug celecoxib were encapsulated within the particles and were shown to be released upon introduction of small amounts of the appropriate stimulus. Initial cell culture studies were performed to investigate the behavior of the systems in vitro. This system provides the ability to tune the responsiveness of the NPs by simply changing the PEtG end-cap, making them a great prospect for stimuli-responsive drug delivery vehicles."]},{"key":"dc:title","label":"Title","values":["Poly(ethyl glyoxylate) Solid-Core Particles for Drug Delivery"]}]}],"canonical_facts":{"dc:contributor.advisor":["Elizabeth Rachel Gillies"],"dc:creator":["Gambles, Michael Thomas"],"dc:date.accessioned":["2025-07-10T15:29:29Z"],"dc:date.available":["2025-07-10T15:29:29Z"],"dc:date.issued":["2017-08-14"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["The ability to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger the release of cargo. Polymeric nanotechnology containing “self-immolative polymers” looks to alleviate the reliance on high concentrations of stimuli by undergoing complete end-to-end depolymerization via a single stimulus-mediated reaction of an end-cap. Herein, NPs were developed using poly(ethyl glyoxylate) (PEtG) blended with poly(d,l-lactic acid) (PLA) to encapsulate a hydrophobic cargo to be released upon stimulus-triggered cleavage of the PEtG end-cap. The PEtG-PLA NPs were formed using an oil-in-water emulsion-evaporation technique. Particles responsive to stimuli including UV light and reducing conditions were prepared and studied. Cleavage of the end-caps of these polymers was accomplished by introducing the relevant stimuli, resulting in a rapid degradation of the particles and subsequent release of cargo. Nile red as a fluorescent probe and the drug celecoxib were encapsulated within the particles and were shown to be released upon introduction of small amounts of the appropriate stimulus. Initial cell culture studies were performed to investigate the behavior of the systems in vitro. 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