{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/27342"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/27342","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Incidence, Characteristics, and Outcomes of Acute Kidney Injury Treated with Dialysis during Pregnancy and the Postpartum Period","abstract":"Pregnancy-related acute kidney injury (AKI) may be associated with significant morbidity and mortality in young and often otherwise healthy women. We conducted a retrospective cohort study of all consecutive pregnancies between 1997 and 2011 in Ontario and describe the incidence, characteristics, and outcomes of AKI treated with dialysis (AKI-D) during pregnancy or within 12 weeks postpartum. Of 1,918,789 pregnancies, 188 were complicated by AKI-D (incidence proportion: 1 per 10,000, 95% confidence interval 0.8 to 1.1). Eight women died (4.3% versus 0.01% in the general population) and seven (3.9%) survivors remained dialysis-dependent four months after delivery. The presence of AKI-D was associated with several maternal complications as well as low birth weight, small for gestational age, and preterm birth among infants, although there were no stillbirths and fewer than five neonatal deaths in affected pregnancies. In conclusion, AKI-D in pregnancy is rare. Most affected women and their babies have good short-term outcomes.","abstract_html":"Pregnancy-related acute kidney injury (AKI) may be associated with significant morbidity and mortality in young and often otherwise healthy women. We conducted a retrospective cohort study of all consecutive pregnancies between 1997 and 2011 in Ontario and describe the incidence, characteristics, and outcomes of AKI treated with dialysis (AKI-D) during pregnancy or within 12 weeks postpartum. Of 1,918,789 pregnancies, 188 were complicated by AKI-D (incidence proportion: 1 per 10,000, 95% confidence interval 0.8 to 1.1). Eight women died (4.3% versus 0.01% in the general population) and seven (3.9%) survivors remained dialysis-dependent four months after delivery. The presence of AKI-D was associated with several maternal complications as well as low birth weight, small for gestational age, and preterm birth among infants, although there were no stillbirths and fewer than five neonatal deaths in affected pregnancies. In conclusion, AKI-D in pregnancy is rare. Most affected women and their babies have good short-term outcomes.","abstract_has_math":false,"creators":["Hildebrand, Ainslie M"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Epidemiology and Biostatistics","degree_department":null,"school":null,"contributors":[],"advisors":["Garg, Amit X."],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-04-13","date_published":"2017-04-13","updated_at":"2026-07-27T21:56:14Z","subjects":["Administrative data","health outcomes","retrospective cohort study","pregnancy","acute kidney injury","dialysis"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/27342","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Garg, Amit X."]},{"key":"dc:creator","label":"Author","values":["Hildebrand, Ainslie M"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T15:29:12Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T15:29:12Z"]},{"key":"dc:date.issued","label":"Date","values":["2017-04-13"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Epidemiology and Biostatistics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Administrative data","health outcomes","retrospective cohort study","pregnancy","acute kidney injury","dialysis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/27342"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Pregnancy-related acute kidney injury (AKI) may be associated with significant morbidity and mortality in young and often otherwise healthy women. We conducted a retrospective cohort study of all consecutive pregnancies between 1997 and 2011 in Ontario and describe the incidence, characteristics, and outcomes of AKI treated with dialysis (AKI-D) during pregnancy or within 12 weeks postpartum. Of 1,918,789 pregnancies, 188 were complicated by AKI-D (incidence proportion: 1 per 10,000, 95% confidence interval 0.8 to 1.1). Eight women died (4.3% versus 0.01% in the general population) and seven (3.9%) survivors remained dialysis-dependent four months after delivery. The presence of AKI-D was associated with several maternal complications as well as low birth weight, small for gestational age, and preterm birth among infants, although there were no stillbirths and fewer than five neonatal deaths in affected pregnancies. In conclusion, AKI-D in pregnancy is rare. Most affected women and their babies have good short-term outcomes."]},{"key":"dc:title","label":"Title","values":["Incidence, Characteristics, and Outcomes of Acute Kidney Injury Treated with Dialysis during Pregnancy and the Postpartum Period"]}]}],"canonical_facts":{"dc:contributor.advisor":["Garg, Amit X."],"dc:creator":["Hildebrand, Ainslie M"],"dc:date.accessioned":["2025-07-10T15:29:12Z"],"dc:date.available":["2025-07-10T15:29:12Z"],"dc:date.issued":["2017-04-13"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Pregnancy-related acute kidney injury (AKI) may be associated with significant morbidity and mortality in young and often otherwise healthy women. We conducted a retrospective cohort study of all consecutive pregnancies between 1997 and 2011 in Ontario and describe the incidence, characteristics, and outcomes of AKI treated with dialysis (AKI-D) during pregnancy or within 12 weeks postpartum. Of 1,918,789 pregnancies, 188 were complicated by AKI-D (incidence proportion: 1 per 10,000, 95% confidence interval 0.8 to 1.1). Eight women died (4.3% versus 0.01% in the general population) and seven (3.9%) survivors remained dialysis-dependent four months after delivery. The presence of AKI-D was associated with several maternal complications as well as low birth weight, small for gestational age, and preterm birth among infants, although there were no stillbirths and fewer than five neonatal deaths in affected pregnancies. In conclusion, AKI-D in pregnancy is rare. Most affected women and their babies have good short-term outcomes."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/27342"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Administrative data","health outcomes","retrospective cohort study","pregnancy","acute kidney injury","dialysis"],"dc:title":["Incidence, Characteristics, and Outcomes of Acute Kidney Injury Treated with Dialysis during Pregnancy and the Postpartum Period"],"dc:type":["thesis"],"thesis:degree_discipline":["Epidemiology and Biostatistics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:14Z"}