{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/27018"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/27018","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Probiotic therapy for heart failure: Investigating the potential anti-hypertrophic properties of probiotics","abstract":"Heart failure patients face a five-year 50% mortality rate, due to impaired cardiac function and hypertrophy of the heart. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Considering the established cardiovascular benefits of some probiotics, including reduction of cholesterol and hypertension, it was hypothesized that probiotics can improve outcomes of heart failure. Probiotics or controls were administered orally to an animal model for heart failure. Those receiving probiotics showed a significant improvement in cardiac hypertrophy and an attenuation of heart failure compared to control. No changes in gut microbial composition occurred. An in vitro model for cardiomyocyte hypertrophy examined the mechanistic action of probiotics in preventing cardiac hypertrophy. Studies showed that probiotics confer a direct anti-hypertrophic benefit to cardiomyocytes. These results support the hypothesis that probiotics can improve outcomes of heart failure and present a novel treatment strategy for heart failure.","abstract_html":"Heart failure patients face a five-year 50% mortality rate, due to impaired cardiac function and hypertrophy of the heart. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Considering the established cardiovascular benefits of some probiotics, including reduction of cholesterol and hypertension, it was hypothesized that probiotics can improve outcomes of heart failure. Probiotics or controls were administered orally to an animal model for heart failure. Those receiving probiotics showed a significant improvement in cardiac hypertrophy and an attenuation of heart failure compared to control. No changes in gut microbial composition occurred. An in vitro model for cardiomyocyte hypertrophy examined the mechanistic action of probiotics in preventing cardiac hypertrophy. Studies showed that probiotics confer a direct anti-hypertrophic benefit to cardiomyocytes. These results support the hypothesis that probiotics can improve outcomes of heart failure and present a novel treatment strategy for heart failure.","abstract_has_math":false,"creators":["Ettinger, Grace L"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Microbiology and Immunology","degree_department":null,"school":null,"contributors":[],"advisors":["Gregor Reid"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-07-04","date_published":"2014-07-04","updated_at":"2026-07-27T21:56:01Z","subjects":["Probiotics","lactobacilli","heart failure","cardiac hypertrophy","cardiomyocytes","microbiome"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/27018","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gregor Reid"]},{"key":"dc:creator","label":"Author","values":["Ettinger, Grace L"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T15:16:40Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T15:16:40Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-07-04"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Microbiology and Immunology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Probiotics","lactobacilli","heart failure","cardiac hypertrophy","cardiomyocytes","microbiome"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/27018"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Supplemental file: Signed supervisor approval for submission","The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Heart failure patients face a five-year 50% mortality rate, due to impaired cardiac function and hypertrophy of the heart. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Considering the established cardiovascular benefits of some probiotics, including reduction of cholesterol and hypertension, it was hypothesized that probiotics can improve outcomes of heart failure. Probiotics or controls were administered orally to an animal model for heart failure. Those receiving probiotics showed a significant improvement in cardiac hypertrophy and an attenuation of heart failure compared to control. No changes in gut microbial composition occurred. An in vitro model for cardiomyocyte hypertrophy examined the mechanistic action of probiotics in preventing cardiac hypertrophy. Studies showed that probiotics confer a direct anti-hypertrophic benefit to cardiomyocytes. These results support the hypothesis that probiotics can improve outcomes of heart failure and present a novel treatment strategy for heart failure."]},{"key":"dc:title","label":"Title","values":["Probiotic therapy for heart failure: Investigating the potential anti-hypertrophic properties of probiotics"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gregor Reid"],"dc:creator":["Ettinger, Grace L"],"dc:date.accessioned":["2025-07-10T15:16:40Z"],"dc:date.available":["2025-07-10T15:16:40Z"],"dc:date.issued":["2014-07-04"],"dc:description":["Supplemental file: Signed supervisor approval for submission","The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Heart failure patients face a five-year 50% mortality rate, due to impaired cardiac function and hypertrophy of the heart. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Considering the established cardiovascular benefits of some probiotics, including reduction of cholesterol and hypertension, it was hypothesized that probiotics can improve outcomes of heart failure. Probiotics or controls were administered orally to an animal model for heart failure. Those receiving probiotics showed a significant improvement in cardiac hypertrophy and an attenuation of heart failure compared to control. No changes in gut microbial composition occurred. An in vitro model for cardiomyocyte hypertrophy examined the mechanistic action of probiotics in preventing cardiac hypertrophy. Studies showed that probiotics confer a direct anti-hypertrophic benefit to cardiomyocytes. These results support the hypothesis that probiotics can improve outcomes of heart failure and present a novel treatment strategy for heart failure."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/27018"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Probiotics","lactobacilli","heart failure","cardiac hypertrophy","cardiomyocytes","microbiome"],"dc:title":["Probiotic therapy for heart failure: Investigating the potential anti-hypertrophic properties of probiotics"],"dc:type":["thesis"],"thesis:degree_discipline":["Microbiology and Immunology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:01Z"}