{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/19943"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/19943","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM","abstract":"The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and a unique murine intranodal implantation model are used to track the movement of iron-labeled melanoma cells in vivo. With these methods we demonstrate, for the first time, that cellular MRI can be used to detect metastatic melanoma cells present at the implant site and in the draining lymph node and to track the growth of these cells into a metastatic tumor. The ability to track metastatic cancer cells in the lymphatic system in vivo may promote a better understanding of models of carcinogenesis and metastasis and in the future may help to improve on principles by which cancers are treated.","abstract_html":"The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and a unique murine intranodal implantation model are used to track the movement of iron-labeled melanoma cells in vivo. With these methods we demonstrate, for the first time, that cellular MRI can be used to detect metastatic melanoma cells present at the implant site and in the draining lymph node and to track the growth of these cells into a metastatic tumor. The ability to track metastatic cancer cells in the lymphatic system in vivo may promote a better understanding of models of carcinogenesis and metastasis and in the future may help to improve on principles by which cancers are treated.","abstract_has_math":false,"creators":["Lui, Tracey Y.M."],"institution":null,"degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["Foster, Paula J."],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-01-01","date_published":"2008-01-01","updated_at":"2026-07-27T21:56:16Z","subjects":["Magnetic Resonance Imaging (MRI)","balanced steady-state free precession (b-SSFP)","superparamagnetic iron-oxide particles (SPIO)","melanoma","B16F10","lymphatic metastasis","mouse model."],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/19943","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Foster, Paula J."]},{"key":"dc:creator","label":"Author","values":["Lui, Tracey Y.M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-06-25T19:12:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-06-25T19:12:42Z"]},{"key":"dc:date.issued","label":"Date","values":["2008-01-01"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Magnetic Resonance Imaging (MRI)","balanced steady-state free precession (b-SSFP)","superparamagnetic iron-oxide particles (SPIO)","melanoma","B16F10","lymphatic metastasis","mouse model."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/19943"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and a unique murine intranodal implantation model are used to track the movement of iron-labeled melanoma cells in vivo. With these methods we demonstrate, for the first time, that cellular MRI can be used to detect metastatic melanoma cells present at the implant site and in the draining lymph node and to track the growth of these cells into a metastatic tumor. The ability to track metastatic cancer cells in the lymphatic system in vivo may promote a better understanding of models of carcinogenesis and metastasis and in the future may help to improve on principles by which cancers are treated."]},{"key":"dc:title","label":"Title","values":["CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM"]}]}],"canonical_facts":{"dc:contributor.advisor":["Foster, Paula J."],"dc:creator":["Lui, Tracey Y.M."],"dc:date.accessioned":["2025-06-25T19:12:42Z"],"dc:date.available":["2025-06-25T19:12:42Z"],"dc:date.issued":["2008-01-01"],"dc:description.abstract":["The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and a unique murine intranodal implantation model are used to track the movement of iron-labeled melanoma cells in vivo. With these methods we demonstrate, for the first time, that cellular MRI can be used to detect metastatic melanoma cells present at the implant site and in the draining lymph node and to track the growth of these cells into a metastatic tumor. The ability to track metastatic cancer cells in the lymphatic system in vivo may promote a better understanding of models of carcinogenesis and metastasis and in the future may help to improve on principles by which cancers are treated."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/19943"],"dc:subject":["Magnetic Resonance Imaging (MRI)","balanced steady-state free precession (b-SSFP)","superparamagnetic iron-oxide particles (SPIO)","melanoma","B16F10","lymphatic metastasis","mouse model."],"dc:title":["CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM"],"dc:type":["thesis"],"thesis:degree_discipline":["Medical Biophysics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:16Z"}