{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/19640"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/19640","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION","abstract":"The fetal development of the islets of Langerhans is dependent on bidirectional signalling with the surrounding capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular system, neonatal rats were injected with streptozotocin to exacerbate this normal loss of β cells. Immunohistochemical and quantitative RNA analysis was performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and growth factors over the subsequent 40 days. Normal islet development involved remodelling of the islet vasculature around weaning which may involve nestin+ cells. Destruction of β cells resulted in a disruption of the islet microvasculature. Re-organization of both tissue compartments appears to be co-ordinated around weaning in normal islet development and following β cell loss.","abstract_html":"The fetal development of the islets of Langerhans is dependent on bidirectional signalling with the surrounding capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular system, neonatal rats were injected with streptozotocin to exacerbate this normal loss of β cells. Immunohistochemical and quantitative RNA analysis was performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and growth factors over the subsequent 40 days. Normal islet development involved remodelling of the islet vasculature around weaning which may involve nestin+ cells. Destruction of β cells resulted in a disruption of the islet microvasculature. Re-organization of both tissue compartments appears to be co-ordinated around weaning in normal islet development and following β cell loss.","abstract_has_math":false,"creators":["Nicholson, John Michael Ross"],"institution":null,"degree_name":"M Sc","degree_level":null,"degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":[],"advisors":["Hill, David","Arany, Edith","Wang, Rennian"],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-01-01","date_published":"2008-01-01","updated_at":"2026-07-27T21:56:07Z","subjects":["beta cell regeneration","islet micro vasculature","neonatal islet development","streptozotocin","vascular endothelial growth factor","hepatocyte growth factor."],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/19640","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hill, David","Arany, Edith","Wang, Rennian"]},{"key":"dc:creator","label":"Author","values":["Nicholson, John Michael Ross"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-06-25T19:06:40Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-06-25T19:06:40Z"]},{"key":"dc:date.issued","label":"Date","values":["2008-01-01"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["beta cell regeneration","islet micro vasculature","neonatal islet development","streptozotocin","vascular endothelial growth factor","hepatocyte growth factor."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/19640"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The fetal development of the islets of Langerhans is dependent on bidirectional signalling with the surrounding capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular system, neonatal rats were injected with streptozotocin to exacerbate this normal loss of β cells. Immunohistochemical and quantitative RNA analysis was performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and growth factors over the subsequent 40 days. Normal islet development involved remodelling of the islet vasculature around weaning which may involve nestin+ cells. Destruction of β cells resulted in a disruption of the islet microvasculature. Re-organization of both tissue compartments appears to be co-ordinated around weaning in normal islet development and following β cell loss."]},{"key":"dc:title","label":"Title","values":["THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hill, David","Arany, Edith","Wang, Rennian"],"dc:creator":["Nicholson, John Michael Ross"],"dc:date.accessioned":["2025-06-25T19:06:40Z"],"dc:date.available":["2025-06-25T19:06:40Z"],"dc:date.issued":["2008-01-01"],"dc:description.abstract":["The fetal development of the islets of Langerhans is dependent on bidirectional signalling with the surrounding capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular system, neonatal rats were injected with streptozotocin to exacerbate this normal loss of β cells. Immunohistochemical and quantitative RNA analysis was performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and growth factors over the subsequent 40 days. Normal islet development involved remodelling of the islet vasculature around weaning which may involve nestin+ cells. Destruction of β cells resulted in a disruption of the islet microvasculature. Re-organization of both tissue compartments appears to be co-ordinated around weaning in normal islet development and following β cell loss."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/19640"],"dc:subject":["beta cell regeneration","islet micro vasculature","neonatal islet development","streptozotocin","vascular endothelial growth factor","hepatocyte growth factor."],"dc:title":["THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION"],"dc:type":["thesis"],"thesis:degree_discipline":["Physiology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:07Z"}