{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/18575"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/18575","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL","abstract":"It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on one side. Contralateral defects in Control, EXP1, and EXP2 were partially filled with native parietal bone (sham), non-vascularized, and vascularized bone grafts, respectively. Healing parameters were measured from serial micro-CT scans. Greater bone production resulted in Control and EXP2 versus EXP1 at later stages. Healing progressed through bone islands within Control and EXP2 versus marginal healing in EXP1. An animal model has been established to study non-vascularized and vascularized calvarial bone grafts. Non-vascularized bone grafts may inhibit dural osteogenesis. Greater understanding o f vascular mechanisms underlying calvarial healing may have implications for cranial reconstruction.","abstract_html":"It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on one side. Contralateral defects in Control, EXP1, and EXP2 were partially filled with native parietal bone (sham), non-vascularized, and vascularized bone grafts, respectively. Healing parameters were measured from serial micro-CT scans. Greater bone production resulted in Control and EXP2 versus EXP1 at later stages. Healing progressed through bone islands within Control and EXP2 versus marginal healing in EXP1. An animal model has been established to study non-vascularized and vascularized calvarial bone grafts. Non-vascularized bone grafts may inhibit dural osteogenesis. Greater understanding o f vascular mechanisms underlying calvarial healing may have implications for cranial reconstruction.","abstract_has_math":false,"creators":["Reid, Stephanie M."],"institution":null,"degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["Holdsworth, David W."],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-01-01","date_published":"2011-01-01","updated_at":"2026-07-27T21:56:16Z","subjects":["Calvarial defect","bone healing","bone graft","non-vascularized","vascularized."],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/18575","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Holdsworth, David W."]},{"key":"dc:creator","label":"Author","values":["Reid, Stephanie M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-06-25T18:51:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-06-25T18:51:39Z"]},{"key":"dc:date.issued","label":"Date","values":["2011-01-01"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Calvarial defect","bone healing","bone graft","non-vascularized","vascularized."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/18575"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on one side. Contralateral defects in Control, EXP1, and EXP2 were partially filled with native parietal bone (sham), non-vascularized, and vascularized bone grafts, respectively. Healing parameters were measured from serial micro-CT scans. Greater bone production resulted in Control and EXP2 versus EXP1 at later stages. Healing progressed through bone islands within Control and EXP2 versus marginal healing in EXP1. An animal model has been established to study non-vascularized and vascularized calvarial bone grafts. Non-vascularized bone grafts may inhibit dural osteogenesis. Greater understanding o f vascular mechanisms underlying calvarial healing may have implications for cranial reconstruction."]},{"key":"dc:title","label":"Title","values":["THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL"]}]}],"canonical_facts":{"dc:contributor.advisor":["Holdsworth, David W."],"dc:creator":["Reid, Stephanie M."],"dc:date.accessioned":["2025-06-25T18:51:39Z"],"dc:date.available":["2025-06-25T18:51:39Z"],"dc:date.issued":["2011-01-01"],"dc:description.abstract":["It remains unknown whether bone grafting influences dural osteogenesis following cranial reconstruction. The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on one side. Contralateral defects in Control, EXP1, and EXP2 were partially filled with native parietal bone (sham), non-vascularized, and vascularized bone grafts, respectively. Healing parameters were measured from serial micro-CT scans. Greater bone production resulted in Control and EXP2 versus EXP1 at later stages. Healing progressed through bone islands within Control and EXP2 versus marginal healing in EXP1. An animal model has been established to study non-vascularized and vascularized calvarial bone grafts. Non-vascularized bone grafts may inhibit dural osteogenesis. Greater understanding o f vascular mechanisms underlying calvarial healing may have implications for cranial reconstruction."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/18575"],"dc:subject":["Calvarial defect","bone healing","bone graft","non-vascularized","vascularized."],"dc:title":["THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL"],"dc:type":["thesis"],"thesis:degree_discipline":["Medical Biophysics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:16Z"}