{"id":{"repo_id":"utswmed","oai_identifier":"oai:utswmed-ir.tdl.org:2152.5/9584"},"canonical_url":"https://search.dev.ndltd.org/etd/utswmed/oai:utswmed-ir.tdl.org:2152.5/9584","repository":{"repo_id":"utswmed","name":"University of Texas Southwestern Medical Center","base_url":"https://utswmed-ir.tdl.org/server/oai/request"},"display":{"title":"Advanced MR Imaging of Bone Marrow: Quantification of Signal Alterations on T1-Weighted Dixon and T2-Weighted Dixon Sequences in Red Marrow, Yellow Marrow and Pathologic Marrow Lesions","abstract":"The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","abstract_html":"The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","abstract_has_math":false,"creators":["Sasiponganan, Chayanit"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Chhabra, Avneesh","Pezeshk, Parham","Ashikyan, Oganes"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-06-03T22:42:24Z","date_published":"2021-06-03T22:42:24Z","updated_at":"2026-07-24T05:52:20Z","subjects":["Bone Marrow","Bone Marrow Neoplasms","Magnetic Resonance Imaging","Signal Processing, Computer-Assisted"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["1255189266"],"render_values":[{"text":"1255189266","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2152.5/9584","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chhabra, Avneesh","Pezeshk, Parham","Ashikyan, Oganes"]},{"key":"dc:creator","label":"Author","values":["Sasiponganan, Chayanit"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-06-03T22:42:24Z","2019-05","2019-03-27","May 2019","2021-06-03T22:42:25Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bone Marrow","Bone Marrow Neoplasms","Magnetic Resonance Imaging","Signal Processing, Computer-Assisted"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2152.5/9584","1255189266"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","BACKGROUND: Characterization of bone marrow through qualitative changes in signal intensity (SI) have not been evaluated on T2-weighted (W) Dixon imaging. OBJECTIVE: We hypothesized that T2W Dixon imaging SI changes are similar to those on T1W Dixon imaging and can be used to effectively characterize bone marrow. METHODS: 144 patients (77 controls with yellow and red marrow regions, 64 lesions--33 benign and 31 malignant) between January 2016 - December 2017 were retrospectively identified. For the control group, fixed 2 cm2 region of interests (ROI) were drawn at L5, bilateral ilium and femurs on in-phase and opposed-phase T1W and T2W Dixon images. For the lesion group, ROI of best fit were drawn around each lesion on in-phase and opposed-phase T2W Dixon images. SI changes for each group were compared. Inter-reader analysis was performed. RESULTS: Yellow marrow exhibited smaller SI changes as compared to red marrow on both T1W and T2W Dixon at all locations (p < 0.0001) except at L5 on T2W Dixon (p = 0.206). Both benign and malignant lesions showed significantly smaller SI changes as compared to both yellow (p = 0.0087, p <0.0001) and red marrow (p = 0.0004, p < 0.0001) on T2W Dixon. Malignant lesions exhibited smaller SI change as compared to benign lesions on T2W Dixon (p = 0.0005). Signal intensity loss on both red and yellow marrow were smaller on T1W Dixon as compared to T2W Dixon (0.49-0.64, 0.27-0.31 vs 0.70-0.74, 0.48-0.71). Inter-reader agreements were excellent (0.91-0.97). CONCLUSION: SI change calculated from T2W Dixon imaging can adequately differentiate between yellow marrow, red marrow and osseous lesions--both benign and malignant."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Advanced MR Imaging of Bone Marrow: Quantification of Signal Alterations on T1-Weighted Dixon and T2-Weighted Dixon Sequences in Red Marrow, Yellow Marrow and Pathologic Marrow Lesions"]}]}],"canonical_facts":{"dc:contributor":["Chhabra, Avneesh","Pezeshk, Parham","Ashikyan, Oganes"],"dc:creator":["Sasiponganan, Chayanit"],"dc:date":["2021-06-03T22:42:24Z","2019-05","2019-03-27","May 2019","2021-06-03T22:42:25Z"],"dc:description":["The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","BACKGROUND: Characterization of bone marrow through qualitative changes in signal intensity (SI) have not been evaluated on T2-weighted (W) Dixon imaging. OBJECTIVE: We hypothesized that T2W Dixon imaging SI changes are similar to those on T1W Dixon imaging and can be used to effectively characterize bone marrow. METHODS: 144 patients (77 controls with yellow and red marrow regions, 64 lesions--33 benign and 31 malignant) between January 2016 - December 2017 were retrospectively identified. For the control group, fixed 2 cm2 region of interests (ROI) were drawn at L5, bilateral ilium and femurs on in-phase and opposed-phase T1W and T2W Dixon images. For the lesion group, ROI of best fit were drawn around each lesion on in-phase and opposed-phase T2W Dixon images. SI changes for each group were compared. Inter-reader analysis was performed. RESULTS: Yellow marrow exhibited smaller SI changes as compared to red marrow on both T1W and T2W Dixon at all locations (p < 0.0001) except at L5 on T2W Dixon (p = 0.206). Both benign and malignant lesions showed significantly smaller SI changes as compared to both yellow (p = 0.0087, p <0.0001) and red marrow (p = 0.0004, p < 0.0001) on T2W Dixon. Malignant lesions exhibited smaller SI change as compared to benign lesions on T2W Dixon (p = 0.0005). Signal intensity loss on both red and yellow marrow were smaller on T1W Dixon as compared to T2W Dixon (0.49-0.64, 0.27-0.31 vs 0.70-0.74, 0.48-0.71). Inter-reader agreements were excellent (0.91-0.97). CONCLUSION: SI change calculated from T2W Dixon imaging can adequately differentiate between yellow marrow, red marrow and osseous lesions--both benign and malignant."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2152.5/9584","1255189266"],"dc:language":["en"],"dc:subject":["Bone Marrow","Bone Marrow Neoplasms","Magnetic Resonance Imaging","Signal Processing, Computer-Assisted"],"dc:title":["Advanced MR Imaging of Bone Marrow: Quantification of Signal Alterations on T1-Weighted Dixon and T2-Weighted Dixon Sequences in Red Marrow, Yellow Marrow and Pathologic Marrow Lesions"],"dc:type":["Thesis","text"]},"updated_at":"2026-07-24T05:52:20Z"}