University of Texas Southwestern Medical Center
Precursor-Directed Identification of Natural Product Scaffolds
Abstract
dc:descriptionThe rapid generation of natural product analogs is a fundamental challenge in both the optimization of medicinal potency and exploration of novel biological activity. Previous work with Streptomyces variabilis has demonstrated that natural products that incorporate non-enzymatic transformation can be exploited for the rapid generation of analogs. Herein we demonstrate a general methodology to use fluorinated or isotopically labeled substrates to identify natural product frameworks prone to non-enzymatic pathways. As proof of principle our precursor directed methodology was used in the study of discoipyrrole A formation, the guided isolation of a novel iminoquinone and the detection of a novel ammosamide analog via incorporation of a carbon-based nucleophile.
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Brumley, David Anderson
- Contributors dc:contributor
-
- MacMillan, John
Subjects
dc:subject × 6Rights
- Language dc:language
- en
Identifiers
dc:identifier.*- Identifier
- 1103324459
- OAI identifier oai:identifier
- oai:utswmed-ir.tdl.org:2152.5/6618