{"id":{"repo_id":"utswmed","oai_identifier":"oai:utswmed-ir.tdl.org:2152.5/4143"},"canonical_url":"https://search.dev.ndltd.org/etd/utswmed/oai:utswmed-ir.tdl.org:2152.5/4143","repository":{"repo_id":"utswmed","name":"University of Texas Southwestern Medical Center","base_url":"https://utswmed-ir.tdl.org/server/oai/request"},"display":{"title":"The Biological Role of Stochasticity from Molecules to Communities","abstract":"The presence of stochasticity in biology engenders the question of the role of such randomness. While stochasticity may be an artifact of biochemical interactions, it could also be an actively regulated aspect of life. Here I investigate how noise may be encoded within the molecular interactions of a biochemical network and then examine how those consequences propagate to higher levels of organization including isogenic populations of cells and host-pathogen interactions. I particularly look into how this variability impacts the ability of populations to respond to their environments. I conclude that stochasticity is selectable property of life that adds robustness to biological processes during periods of uncertainty.","abstract_html":"The presence of stochasticity in biology engenders the question of the role of such randomness. While stochasticity may be an artifact of biochemical interactions, it could also be an actively regulated aspect of life. Here I investigate how noise may be encoded within the molecular interactions of a biochemical network and then examine how those consequences propagate to higher levels of organization including isogenic populations of cells and host-pathogen interactions. I particularly look into how this variability impacts the ability of populations to respond to their environments. I conclude that stochasticity is selectable property of life that adds robustness to biological processes during periods of uncertainty.","abstract_has_math":false,"creators":["Kittisopikul, Mark Andrew"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Ranganathan, Rama","Süel, Gürol M.","Alto, Neal","Rizo-Rey, José"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-06-14T19:31:16Z","date_published":"2017-06-14T19:31:16Z","updated_at":"2026-07-24T05:52:36Z","subjects":["Cell Cycle","Host-Pathogen Interactions","Models, Biological","Stochastic Processes","Systems Biology"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["990065818"],"render_values":[{"text":"990065818","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2152.5/4143","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ranganathan, Rama","Süel, Gürol M.","Alto, Neal","Rizo-Rey, José"]},{"key":"dc:creator","label":"Author","values":["Kittisopikul, Mark Andrew"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2017-06-14T19:31:16Z","2014-05","2013-07-17","May 2014","2017-06-14T19:30:16Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cell Cycle","Host-Pathogen Interactions","Models, Biological","Stochastic Processes","Systems Biology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2152.5/4143","990065818"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The presence of stochasticity in biology engenders the question of the role of such randomness. While stochasticity may be an artifact of biochemical interactions, it could also be an actively regulated aspect of life. Here I investigate how noise may be encoded within the molecular interactions of a biochemical network and then examine how those consequences propagate to higher levels of organization including isogenic populations of cells and host-pathogen interactions. I particularly look into how this variability impacts the ability of populations to respond to their environments. I conclude that stochasticity is selectable property of life that adds robustness to biological processes during periods of uncertainty."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Biological Role of Stochasticity from Molecules to Communities"]}]}],"canonical_facts":{"dc:contributor":["Ranganathan, Rama","Süel, Gürol M.","Alto, Neal","Rizo-Rey, José"],"dc:creator":["Kittisopikul, Mark Andrew"],"dc:date":["2017-06-14T19:31:16Z","2014-05","2013-07-17","May 2014","2017-06-14T19:30:16Z"],"dc:description":["The presence of stochasticity in biology engenders the question of the role of such randomness. While stochasticity may be an artifact of biochemical interactions, it could also be an actively regulated aspect of life. Here I investigate how noise may be encoded within the molecular interactions of a biochemical network and then examine how those consequences propagate to higher levels of organization including isogenic populations of cells and host-pathogen interactions. I particularly look into how this variability impacts the ability of populations to respond to their environments. I conclude that stochasticity is selectable property of life that adds robustness to biological processes during periods of uncertainty."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2152.5/4143","990065818"],"dc:language":["en"],"dc:subject":["Cell Cycle","Host-Pathogen Interactions","Models, Biological","Stochastic Processes","Systems Biology"],"dc:title":["The Biological Role of Stochasticity from Molecules to Communities"],"dc:type":["Thesis","text"]},"updated_at":"2026-07-24T05:52:36Z"}