{"id":{"repo_id":"utswmed","oai_identifier":"oai:utswmed-ir.tdl.org:2152.5/3318"},"canonical_url":"https://search.dev.ndltd.org/etd/utswmed/oai:utswmed-ir.tdl.org:2152.5/3318","repository":{"repo_id":"utswmed","name":"University of Texas Southwestern Medical Center","base_url":"https://utswmed-ir.tdl.org/server/oai/request"},"display":{"title":"Health-Related Quality of Life in Morphea","abstract":"OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. METHODS: Cross sectional survey of Morphea in Adults and Children (MAC) cohort. RESULTS: Morphea impairs HRQOL. Patients were particularly affected with respect to emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. CONCLUSION: Patients with morphea have negative impact on HRQOL particularly if symptoms or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients.","abstract_html":"OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. METHODS: Cross sectional survey of Morphea in Adults and Children (MAC) cohort. RESULTS: Morphea impairs HRQOL. Patients were particularly affected with respect to emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. CONCLUSION: Patients with morphea have negative impact on HRQOL particularly if symptoms or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients.","abstract_has_math":false,"creators":["Klimas, Natasha"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Jacobe, Heidi","Bernstein, Ira","Cayce, Rachael"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-06-27T20:09:43Z","date_published":"2016-06-27T20:09:43Z","updated_at":"2026-07-24T05:52:29Z","subjects":["Emotions","Quality of Life","Scleroderma, Localized"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["952355703"],"render_values":[{"text":"952355703","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2152.5/3318","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jacobe, Heidi","Bernstein, Ira","Cayce, Rachael"]},{"key":"dc:creator","label":"Author","values":["Klimas, Natasha"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-06-27T20:09:43Z","2014-05","2015-03-20","May 2014","2016-06-27T19:49:07Z"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Emotions","Quality of Life","Scleroderma, Localized"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2152.5/3318","952355703"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. METHODS: Cross sectional survey of Morphea in Adults and Children (MAC) cohort. RESULTS: Morphea impairs HRQOL. Patients were particularly affected with respect to emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. CONCLUSION: Patients with morphea have negative impact on HRQOL particularly if symptoms or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Health-Related Quality of Life in Morphea"]}]}],"canonical_facts":{"dc:contributor":["Jacobe, Heidi","Bernstein, Ira","Cayce, Rachael"],"dc:creator":["Klimas, Natasha"],"dc:date":["2016-06-27T20:09:43Z","2014-05","2015-03-20","May 2014","2016-06-27T19:49:07Z"],"dc:description":["OBJECTIVE: Little is known about health-related quality of life (HRQOL) of patients with morphea (localized scleroderma). We determined the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL. METHODS: Cross sectional survey of Morphea in Adults and Children (MAC) cohort. RESULTS: Morphea impairs HRQOL. Patients were particularly affected with respect to emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. CONCLUSION: Patients with morphea have negative impact on HRQOL particularly if symptoms or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2152.5/3318","952355703"],"dc:language":["en_US"],"dc:subject":["Emotions","Quality of Life","Scleroderma, Localized"],"dc:title":["Health-Related Quality of Life in Morphea"],"dc:type":["Thesis","text"]},"updated_at":"2026-07-24T05:52:29Z"}