{"id":{"repo_id":"utswmed","oai_identifier":"oai:utswmed-ir.tdl.org:2152.5/10827"},"canonical_url":"https://search.dev.ndltd.org/etd/utswmed/oai:utswmed-ir.tdl.org:2152.5/10827","repository":{"repo_id":"utswmed","name":"University of Texas Southwestern Medical Center","base_url":"https://utswmed-ir.tdl.org/server/oai/request"},"display":{"title":"A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence","abstract":"The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","abstract_html":"The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","abstract_has_math":false,"creators":["Cheng, Yujing"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Hon, Gary C.","Buszczak, Michael","Liu, Yi","Mendell, Joshua T."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-06-15T19:45:48Z","date_published":"2026-06-15T19:45:48Z","updated_at":"2026-07-24T05:52:34Z","subjects":["Cellular Senescence","RNA, Small Nucleolar","Ribosomal Proteins","Ribosomes","Tumor Suppressor Protein p53"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["1596185260"],"render_values":[{"text":"1596185260","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2152.5/10827","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hon, Gary C.","Buszczak, Michael","Liu, Yi","Mendell, Joshua T."]},{"key":"dc:creator","label":"Author","values":["Cheng, Yujing"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-06-15T19:45:48Z","2024-05","May 2024"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cellular Senescence","RNA, Small Nucleolar","Ribosomal Proteins","Ribosomes","Tumor Suppressor Protein p53"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2152.5/10827","1596185260"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved snoRNA, SNORA13, that is required for multiple forms of senescence. Although SNORA13 guides the pseudouridylation of a highly conserved nucleotide in the ribosomal decoding center, loss of this snoRNA minimally impacts translation. Instead, we found that SNORA13 negatively regulates ribosome biogenesis. Senescence-inducing stress perturbs ribosome biogenesis, resulting in the accumulation of free ribosomal proteins (RPs) that trigger p53 activation. SNORA13 interacts directly with RPL23, decreasing its incorporation into maturing 60S subunits and, consequently, increasing the pool of free RPs, thereby promoting the p53-mediated senescence program. Thus, SNORA13 regulates ribosome biogenesis and the p53 pathway through a non-canonical mechanism distinct from its role in guiding RNA modification. These findings expand our understanding of snoRNA functions and their roles in cellular signaling."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence"]}]}],"canonical_facts":{"dc:contributor":["Hon, Gary C.","Buszczak, Michael","Liu, Yi","Mendell, Joshua T."],"dc:creator":["Cheng, Yujing"],"dc:date":["2026-06-15T19:45:48Z","2024-05","May 2024"],"dc:description":["The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.","Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved snoRNA, SNORA13, that is required for multiple forms of senescence. Although SNORA13 guides the pseudouridylation of a highly conserved nucleotide in the ribosomal decoding center, loss of this snoRNA minimally impacts translation. Instead, we found that SNORA13 negatively regulates ribosome biogenesis. Senescence-inducing stress perturbs ribosome biogenesis, resulting in the accumulation of free ribosomal proteins (RPs) that trigger p53 activation. SNORA13 interacts directly with RPL23, decreasing its incorporation into maturing 60S subunits and, consequently, increasing the pool of free RPs, thereby promoting the p53-mediated senescence program. Thus, SNORA13 regulates ribosome biogenesis and the p53 pathway through a non-canonical mechanism distinct from its role in guiding RNA modification. These findings expand our understanding of snoRNA functions and their roles in cellular signaling."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2152.5/10827","1596185260"],"dc:language":["en"],"dc:subject":["Cellular Senescence","RNA, Small Nucleolar","Ribosomal Proteins","Ribosomes","Tumor Suppressor Protein p53"],"dc:title":["A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence"],"dc:type":["Thesis","text"]},"updated_at":"2026-07-24T05:52:34Z"}