{"id":{"repo_id":"uts","oai_identifier":"oai:opus.lib.uts.edu.au:10453/187347"},"canonical_url":"https://search.dev.ndltd.org/etd/uts/oai:opus.lib.uts.edu.au:10453/187347","repository":{"repo_id":"uts","name":"University of Technology Sydney","base_url":"https://opus.lib.uts.edu.au/oai/request"},"display":{"title":"Development Of New Therapy to Combat Tuberculosis Induced Inflammation","abstract":"Tuberculosis (TB) is a major global health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies examining the FhHDM-1 peptide showed it was able to inhibit the secretion of the pro-inflammatory cytokines, TNF and IL-6, in human macrophages. Treatment of M. tuberculosis infected mice with FhHDM-1 also significantly reduced lung inflammation without reducing control of the bacteria. This research identified two pathways to reduce inflammation during M. tuberculosis infection. Further studies with these anti-inflammatories will hopefully lead to new treatments to reduce TB induced lung damage.","abstract_html":"Tuberculosis (TB) is a major global health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies examining the FhHDM-1 peptide showed it was able to inhibit the secretion of the pro-inflammatory cytokines, TNF and IL-6, in human macrophages. Treatment of M. tuberculosis infected mice with FhHDM-1 also significantly reduced lung inflammation without reducing control of the bacteria. This research identified two pathways to reduce inflammation during M. tuberculosis infection. Further studies with these anti-inflammatories will hopefully lead to new treatments to reduce TB induced lung damage.","abstract_has_math":false,"creators":["Le, Giang Hoang Bao"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024","date_published":"2024","updated_at":"2026-07-24T06:32:35Z","subjects":[],"languages":["en_US"],"rights":["info:eu-repo/semantics/embargoedAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.","© 2024 Giang Hoang Bao Le","au.edu.uts.lib/cph"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10453/187347","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Le, Giang Hoang Bao"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-05-13T04:55:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-05-13T04:55:22Z"]},{"key":"dc:date.issued","label":"Date","values":["2024"]},{"key":"dc:relation","label":"Dc Relation","values":["https://opus.lib.uts.edu.au/bitstream/10453/187347/1/thesis.pdf"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/embargoedAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.","© 2024 Giang Hoang Bao Le","au.edu.uts.lib/cph"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10453/187347"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["University of Technology Sydney. Faculty of Science."]},{"key":"dc:description.abstract","label":"Abstract","values":["Tuberculosis (TB) is a major global health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies examining the FhHDM-1 peptide showed it was able to inhibit the secretion of the pro-inflammatory cytokines, TNF and IL-6, in human macrophages. Treatment of M. tuberculosis infected mice with FhHDM-1 also significantly reduced lung inflammation without reducing control of the bacteria. This research identified two pathways to reduce inflammation during M. tuberculosis infection. Further studies with these anti-inflammatories will hopefully lead to new treatments to reduce TB induced lung damage."]},{"key":"dc:format","label":"Dc Format","values":["Thesis (PhD)"]},{"key":"dc:title","label":"Title","values":["Development Of New Therapy to Combat Tuberculosis Induced Inflammation"]}]}],"canonical_facts":{"dc:creator":["Le, Giang Hoang Bao"],"dc:date.accessioned":["2025-05-13T04:55:22Z"],"dc:date.available":["2025-05-13T04:55:22Z"],"dc:date.issued":["2024"],"dc:description":["University of Technology Sydney. Faculty of Science."],"dc:description.abstract":["Tuberculosis (TB) is a major global health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies examining the FhHDM-1 peptide showed it was able to inhibit the secretion of the pro-inflammatory cytokines, TNF and IL-6, in human macrophages. Treatment of M. tuberculosis infected mice with FhHDM-1 also significantly reduced lung inflammation without reducing control of the bacteria. This research identified two pathways to reduce inflammation during M. tuberculosis infection. Further studies with these anti-inflammatories will hopefully lead to new treatments to reduce TB induced lung damage."],"dc:format":["Thesis (PhD)"],"dc:identifier.uri":["http://hdl.handle.net/10453/187347"],"dc:language.iso":["en_US"],"dc:relation":["https://opus.lib.uts.edu.au/bitstream/10453/187347/1/thesis.pdf"],"dc:rights":["info:eu-repo/semantics/embargoedAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.","© 2024 Giang Hoang Bao Le","au.edu.uts.lib/cph"],"dc:title":["Development Of New Therapy to Combat Tuberculosis Induced Inflammation"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T06:32:35Z"}