{"id":{"repo_id":"uts","oai_identifier":"oai:opus.lib.uts.edu.au:10453/172746"},"canonical_url":"https://search.dev.ndltd.org/etd/uts/oai:opus.lib.uts.edu.au:10453/172746","repository":{"repo_id":"uts","name":"University of Technology Sydney","base_url":"https://opus.lib.uts.edu.au/oai/request"},"display":{"title":"Development of Precision 3D-Printed Medical Implants","abstract":"This research investigated the cellular efficacies of combining biocompatibility and antibacterial properties in biomedical materials. The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity.","abstract_html":"This research investigated the cellular efficacies of combining biocompatibility and antibacterial properties in biomedical materials. The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity.","abstract_has_math":false,"creators":["Wazir, Hakim Ullah"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-24T06:32:12Z","subjects":[],"languages":["en_US"],"rights":["info:eu-repo/semantics/openAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.","© 2023 Hakim Ullah Wazir","au.edu.uts.lib/cph"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10453/172746","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Wazir, Hakim Ullah"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2023-10-17T21:25:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2023-10-17T21:25:22Z"]},{"key":"dc:date.issued","label":"Date","values":["2023"]},{"key":"dc:relation","label":"Dc Relation","values":["https://opus.lib.uts.edu.au/bitstream/10453/172746/1/thesis.pdf"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. 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The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity."]},{"key":"dc:format","label":"Dc Format","values":["Thesis (PhD)"]},{"key":"dc:title","label":"Title","values":["Development of Precision 3D-Printed Medical Implants"]}]}],"canonical_facts":{"dc:creator":["Wazir, Hakim Ullah"],"dc:date.accessioned":["2023-10-17T21:25:22Z"],"dc:date.available":["2023-10-17T21:25:22Z"],"dc:date.issued":["2023"],"dc:description":["University of Technology Sydney. Faculty of Engineering and Information Technology."],"dc:description.abstract":["This research investigated the cellular efficacies of combining biocompatibility and antibacterial properties in biomedical materials. The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity."],"dc:format":["Thesis (PhD)"],"dc:identifier.uri":["http://hdl.handle.net/10453/172746"],"dc:language.iso":["en_US"],"dc:relation":["https://opus.lib.uts.edu.au/bitstream/10453/172746/1/thesis.pdf"],"dc:rights":["info:eu-repo/semantics/openAccess","The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.","© 2023 Hakim Ullah Wazir","au.edu.uts.lib/cph"],"dc:title":["Development of Precision 3D-Printed Medical Implants"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T06:32:12Z"}