Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

Disruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor antagonists prior to acute or sub-chronic PCP. This study provides evidence that two distinct mechanisms underlie effects of acute and sub-chronic PCP on NMDA receptor subunit up-regulation. Furthermore, we discovered that D1, D2, and 5-HT2A receptors play a pivotal role in sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Master

Grantor

The University of Texas Medical Branch

Year dc:date.issued

2005

Author dc:creator

• Noelle Catherine Anastasio

Advisor dc:contributor.advisor

• Kenneth M. Johnson, PhD.

Committee members dc:contributor.committeemember

• Kathryn Cunningham, PhD.
• Giulio Taglialatela, PhD.
• Geoffrey T. Swanson

• schizophrenia
• olanzapine
• animal model

Statement dc:rights

• Copyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.

Language dc:language.iso

eng

Dc Identifier Other

etd-07202005-145246

OAI identifier oai:identifier

oai:utmb-ir.tdl.org:2152.3/170