Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue

Voltage-gated sodium (Nav) channels play a critical role in the initiation and propagation of action potentials in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they lack isoform selectivity, leading to unwanted side effects. Protein-protein interactions regulate Nav channel function and represent a promising target for developing new drugs. Understanding the protein-protein interaction network of Nav channels will provide new therapeutic targets to tackle the lack of Nav isoform selectivity by current therapeutics. This study aimed to discover protein partners that interact with Nav1.6, a predominant isoform in the central nervous system, in different environmental conditions, with the premise that these could serve as druggable targets to improve treatment outcomes.

Name thesis:degree_name

Pharmacology and Toxicology (Masters)

Discipline thesis:degree_discipline

Neuropharmacology

Grantor

The University of Texas Medical Branch at Galveston

Year dc:date.issued

2023

Author dc:creator

• Goode, Nana Aboadwe

Advisor dc:contributor.advisor

• Laezza, Fernanda

Language dc:language.iso

English

Handle dc:identifier.uri

https://hdl.handle.net/2152.3/12842

OAI identifier oai:identifier

oai:utmb-ir.tdl.org:2152.3/12842