University of Tennessee at Chattanooga
Numerical investigation of airflow and aerosol deposition characteristics within human airways
Abstract
dc:description.abstractAerosolized drug delivery in human airways is typically used for the treatment of several pulmonary diseases. In this study, large-eddy simulation (LES) is used for the numerical investigation of the airflow and the aerosol deposition characteristics within the upper human airways. LES is performed using the Eulerian-Lagrangian framework where the airflow is modeled using the Eulerian formulation, and the aerosol evolution is tracked in a Lagrangian manner under the dilute suspension conditions using a one-way coupled approach. First, computational framework is assessed in terms of the prediction of the mean flow statistics and the aerosol deposition and comparing with the past experimental and numerical results. Afterward, the effects of inflow Reynolds number (Re) and particle size (d_p) on the deposition fraction (D_F) are examined. The study shows that the effect of Re on D_F is apparent for d_p>5 μm and D_f increases with an increase in d_p.
Degree
thesis:*- Grantor dc:publisher
- University of Tennessee at Chattanooga
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Mahida, Divyajit
- Contributors dc:contributor
-
- Ranjan, Reetesh
- Sreenivas, Kidambi; Margraves, Charles
- College of Engineering and Computer Science
Subjects
dc:subject × 2Rights
dc:rights- Language dc:language
- English, eng
Identifiers
dc:identifier.*- Repository record dc:identifier
- https://scholar.utc.edu/theses/710
- OAI identifier oai:identifier
- oai:scholar.utc.edu:theses-1876