{"id":{"repo_id":"utc","oai_identifier":"oai:scholar.utc.edu:theses-1480"},"canonical_url":"https://search.dev.ndltd.org/etd/utc/oai:scholar.utc.edu:theses-1480","repository":{"repo_id":"utc","name":"University of Tennessee - Chattanooga","base_url":"https://scholar.utc.edu/do/oai/"},"display":{"title":"Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN","abstract":"Infants born below 2,500 grams are classified as low birth w eight. Reduced birth weight has been shown to increase the risk of infant mortality and chronic adulthood diseases. In 2007, Hamilton Country reported 12.0% of live births to be low birth weight, compared to the state average of 9.4%. An excess in utero exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A Spearman's rank correlation reported a significant correlation between these two variables (p = 0.024). Additionally, birth weight was significantly different between underweight and obese mothers, married vs. single mothers and black vs. white mothers. These results reinforce the importance of proper 11β-HSD2 expression for optimal fetal growth.","abstract_html":"Infants born below 2,500 grams are classified as low birth w eight. Reduced birth weight has been shown to increase the risk of infant mortality and chronic adulthood diseases. In 2007, Hamilton Country reported 12.0% of live births to be low birth weight, compared to the state average of 9.4%. An excess in utero exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A Spearman's rank correlation reported a significant correlation between these two variables (p = 0.024). Additionally, birth weight was significantly different between underweight and obese mothers, married vs. single mothers and black vs. white mothers. These results reinforce the importance of proper 11β-HSD2 expression for optimal fetal growth.","abstract_has_math":false,"creators":["Mikelson, Colleen Katherine"],"institution":"University of Tennessee at Chattanooga","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Richards, Sean M.","Kovach, Margaret J.; Symes, Steve; Adair, C. David","College of Arts and Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-24T05:46:28Z","subjects":["Birth weight, Low"],"languages":["English","eng"],"rights":[],"rights_urls":["https://rightsstatements.org/page/InC/1.0/?language=en"],"identifier_entries":[]},"links":{"outbound_url":"https://scholar.utc.edu/theses/340","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Richards, Sean M.","Kovach, Margaret J.; Symes, Steve; Adair, C. David","College of Arts and Sciences"]},{"key":"dc:creator","label":"Author","values":["Mikelson, Colleen Katherine"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2012-05-01T07:00:00Z"]},{"key":"dc:publisher","label":"Institution","values":["University of Tennessee at Chattanooga","Chattanooga (Tenn.)"]},{"key":"dc:relation","label":"Dc Relation","values":["Masters Theses and Doctoral Dissertations"]},{"key":"dc:type","label":"Dc Type","values":["Masters theses","Text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Birth weight, Low"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["https://rightsstatements.org/page/InC/1.0/?language=en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholar.utc.edu/theses/340"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Dept. of Biological and Environmental Sciences","M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science."]},{"key":"dc:description.abstract","label":"Abstract","values":["Infants born below 2,500 grams are classified as low birth w eight. Reduced birth weight has been shown to increase the risk of infant mortality and chronic adulthood diseases. In 2007, Hamilton Country reported 12.0% of live births to be low birth weight, compared to the state average of 9.4%. An excess in utero exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A Spearman's rank correlation reported a significant correlation between these two variables (p = 0.024). Additionally, birth weight was significantly different between underweight and obese mothers, married vs. single mothers and black vs. white mothers. These results reinforce the importance of proper 11β-HSD2 expression for optimal fetal growth."]},{"key":"dc:title","label":"Title","values":["Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN"]}]}],"canonical_facts":{"dc:contributor":["Richards, Sean M.","Kovach, Margaret J.; Symes, Steve; Adair, C. David","College of Arts and Sciences"],"dc:creator":["Mikelson, Colleen Katherine"],"dc:date":["2012-05-01T07:00:00Z"],"dc:description":["Dept. of Biological and Environmental Sciences","M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science."],"dc:description.abstract":["Infants born below 2,500 grams are classified as low birth w eight. Reduced birth weight has been shown to increase the risk of infant mortality and chronic adulthood diseases. In 2007, Hamilton Country reported 12.0% of live births to be low birth weight, compared to the state average of 9.4%. An excess in utero exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A Spearman's rank correlation reported a significant correlation between these two variables (p = 0.024). Additionally, birth weight was significantly different between underweight and obese mothers, married vs. single mothers and black vs. white mothers. These results reinforce the importance of proper 11β-HSD2 expression for optimal fetal growth."],"dc:identifier":["https://scholar.utc.edu/theses/340"],"dc:language":["English","eng"],"dc:publisher":["University of Tennessee at Chattanooga","Chattanooga (Tenn.)"],"dc:relation":["Masters Theses and Doctoral Dissertations"],"dc:rights":["https://rightsstatements.org/page/InC/1.0/?language=en"],"dc:subject":["Birth weight, Low"],"dc:title":["Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN"],"dc:type":["Masters theses","Text"]},"updated_at":"2026-07-24T05:46:28Z"}