{"id":{"repo_id":"utc","oai_identifier":"oai:scholar.utc.edu:theses-1054"},"canonical_url":"https://search.dev.ndltd.org/etd/utc/oai:scholar.utc.edu:theses-1054","repository":{"repo_id":"utc","name":"University of Tennessee - Chattanooga","base_url":"https://scholar.utc.edu/do/oai/"},"display":{"title":"Hazard assessment of a mixture of pharmaceuticals detected in the upper Tennessee River of Daphnia magna and the determination of riverine zooplankton assemblage as it relates to chitobiase activity","abstract":"In order to respond to the need for hazard assessment of environmentally relevant pharmaceutical mixtures, 21-d life cycle tests were performed on a mixture of pharmaceuticals found in the Tennessee River using Daphnia- magna as a surrogate. Endpoints measured were time to first brood, reproduction, mortality, and number of neonates produced per adult reproduction day. Reproduction was the only endpoint that showed a significant effect. The LOEC of the pharmaceutical mixture was found at 100 times (100x) greater concentration (p=0.005) than what was detected in the Tennessee River. Similarly, the NOEC was 75x (p=0.150). Single concentrations of pharmaceuticals within the mixture up to the LOEC were found to have no effect. Thus, no single pharmaceutical was responsible for the mixture LOEC. To determine if chitobiase can be used to predict secondary production, chitobiase activity and zooplankton density and biomass samples were measured in six Tennessee River tributaries.","abstract_html":"In order to respond to the need for hazard assessment of environmentally relevant pharmaceutical mixtures, 21-d life cycle tests were performed on a mixture of pharmaceuticals found in the Tennessee River using Daphnia- magna as a surrogate. Endpoints measured were time to first brood, reproduction, mortality, and number of neonates produced per adult reproduction day. Reproduction was the only endpoint that showed a significant effect. The LOEC of the pharmaceutical mixture was found at 100 times (100x) greater concentration (p=0.005) than what was detected in the Tennessee River. Similarly, the NOEC was 75x (p=0.150). Single concentrations of pharmaceuticals within the mixture up to the LOEC were found to have no effect. Thus, no single pharmaceutical was responsible for the mixture LOEC. To determine if chitobiase can be used to predict secondary production, chitobiase activity and zooplankton density and biomass samples were measured in six Tennessee River tributaries.","abstract_has_math":false,"creators":["Wolfe, Daniel Neil"],"institution":"University of Tennessee at Chattanooga","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Richards, Sean M.","Schorr, Mark S.; Nelson, Charles H.","College of Arts and Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-24T05:46:02Z","subjects":["Daphnia magna","Freshwater zooplankton","Marine pollution"],"languages":["English","eng"],"rights":[],"rights_urls":["https://rightsstatements.org/page/InC/1.0/?language=en"],"identifier_entries":[]},"links":{"outbound_url":"https://scholar.utc.edu/theses/68","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Richards, Sean M.","Schorr, Mark S.; Nelson, Charles H.","College of Arts and Sciences"]},{"key":"dc:creator","label":"Author","values":["Wolfe, Daniel Neil"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["Tennessee River"]},{"key":"dc:date","label":"Dc Date","values":["2012-05-01T07:00:00Z"]},{"key":"dc:publisher","label":"Institution","values":["University of Tennessee at Chattanooga","Chattanooga (Tenn.)"]},{"key":"dc:relation","label":"Dc Relation","values":["Masters Theses and Doctoral Dissertations"]},{"key":"dc:type","label":"Dc Type","values":["Masters theses","Text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Daphnia magna","Freshwater zooplankton","Marine pollution"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["https://rightsstatements.org/page/InC/1.0/?language=en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholar.utc.edu/theses/68"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Dept. of Biological and Environmental Sciences","M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science."]},{"key":"dc:description.abstract","label":"Abstract","values":["In order to respond to the need for hazard assessment of environmentally relevant pharmaceutical mixtures, 21-d life cycle tests were performed on a mixture of pharmaceuticals found in the Tennessee River using Daphnia- magna as a surrogate. Endpoints measured were time to first brood, reproduction, mortality, and number of neonates produced per adult reproduction day. Reproduction was the only endpoint that showed a significant effect. The LOEC of the pharmaceutical mixture was found at 100 times (100x) greater concentration (p=0.005) than what was detected in the Tennessee River. Similarly, the NOEC was 75x (p=0.150). Single concentrations of pharmaceuticals within the mixture up to the LOEC were found to have no effect. Thus, no single pharmaceutical was responsible for the mixture LOEC. To determine if chitobiase can be used to predict secondary production, chitobiase activity and zooplankton density and biomass samples were measured in six Tennessee River tributaries."]},{"key":"dc:title","label":"Title","values":["Hazard assessment of a mixture of pharmaceuticals detected in the upper Tennessee River of Daphnia magna and the determination of riverine zooplankton assemblage as it relates to chitobiase activity"]}]}],"canonical_facts":{"dc:contributor":["Richards, Sean M.","Schorr, Mark S.; Nelson, Charles H.","College of Arts and Sciences"],"dc:coverage":["Tennessee River"],"dc:creator":["Wolfe, Daniel Neil"],"dc:date":["2012-05-01T07:00:00Z"],"dc:description":["Dept. of Biological and Environmental Sciences","M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science."],"dc:description.abstract":["In order to respond to the need for hazard assessment of environmentally relevant pharmaceutical mixtures, 21-d life cycle tests were performed on a mixture of pharmaceuticals found in the Tennessee River using Daphnia- magna as a surrogate. Endpoints measured were time to first brood, reproduction, mortality, and number of neonates produced per adult reproduction day. Reproduction was the only endpoint that showed a significant effect. The LOEC of the pharmaceutical mixture was found at 100 times (100x) greater concentration (p=0.005) than what was detected in the Tennessee River. Similarly, the NOEC was 75x (p=0.150). Single concentrations of pharmaceuticals within the mixture up to the LOEC were found to have no effect. Thus, no single pharmaceutical was responsible for the mixture LOEC. To determine if chitobiase can be used to predict secondary production, chitobiase activity and zooplankton density and biomass samples were measured in six Tennessee River tributaries."],"dc:identifier":["https://scholar.utc.edu/theses/68"],"dc:language":["English","eng"],"dc:publisher":["University of Tennessee at Chattanooga","Chattanooga (Tenn.)"],"dc:relation":["Masters Theses and Doctoral Dissertations"],"dc:rights":["https://rightsstatements.org/page/InC/1.0/?language=en"],"dc:subject":["Daphnia magna","Freshwater zooplankton","Marine pollution"],"dc:title":["Hazard assessment of a mixture of pharmaceuticals detected in the upper Tennessee River of Daphnia magna and the determination of riverine zooplankton assemblage as it relates to chitobiase activity"],"dc:type":["Masters theses","Text"]},"updated_at":"2026-07-24T05:46:02Z"}