The Assessment of Autonomic Function in Young Adults with an Elevated Risk of Metabolic Syndrome

<p>Metabolic syndrome (MetS) is a complex medical condition defined by the co-occurrence of multiple cardiometabolic risk factors. Despite the well-defined profile of autonomic function in individuals with MetS, autonomic function in those with an elevated risk of developing MetS remains unclear. Our study aimed to shed light on the progression of cardiometabolic disease and its impact on autonomic function. To investigate, twenty participants, ten of whom were classified as having an elevated risk of developing MetS based on identification of risk factors using NCEP ATP III criteria, completed a two-visit study protocol. In the second visit, spontaneous cardiovagal baroreflex sensitivity (cBRS) and heart rate variability (HRV) were evaluated during ten minutes of supine rest, where heart rate (HR), beat-by-beat blood pressure (BP), and breathing frequency were recorded continuously and analyzed using the sequence method (SBP change >1.0mmHg, pulse interval change >5.0ms, r>0.80, sequence length >3 beats). Metaboreflex (MMX) responses were evaluated during 8 minutes of rhythmic handgrip at 25% maximal voluntary contraction (MVC), where HR, beat-by-by BP, and tissue oxygen saturation index (TSI) were recorded continuously. The change in mean arterial pressure vs the change in TSI were plotted to produce a slope quantifying the magnitude of the response. We found that individuals with an elevated risk of developing MetS had significantly impaired cBRS(p</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Masters Thesis

Year dc:date.available

2024

Author dc:creator

• Newsome, Ta'Quoris

Contributors dc:contributor

• Jon Stavres
• Austin Graybeal
• Riley Galloway

• MetS
• Autonomic Dysfunction
• cBRS
• HRV
• MMX
• Kinesiology
• Life Sciences

Repository record dc:identifier

https://aquila.usm.edu/masters_theses/1033

OAI identifier oai:identifier

oai:aquila.usm.edu:masters_theses-2107