Prolonged sitting can cause adverse vascular responses, including elevations in aortic stiffness which might contribute to cardiovascular disease (CVD). Few studies have investigated the impact of intermittent standing and/or prior exercise as strategies to mitigate these deleterious vascular changes. Purpose: to explore vascular health responses to prolonged sitting, with and without intermittent standing and/or prior exercise. Methods: 15 males aged between 18 and 31 years were recruited. Participants completed a control condition (Sitting Only), and three randomized strategy conditions (Sitting Plus Standing, Exercise Plus Sitting, Exercise Plus Sitting Plus Standing). For all conditions, measurements of carotid-femoral PWV (cfPWV) were taken at pre- and post-intervention, and brachial and central blood pressure (BP) at pre-, 1-hour-, 2-hours-, and 3-hours-intervention. Results: Condition and time did not interact significantly for any vascular parameters. cfPWV significantly increased from pre- to post-intervention for all conditions (p=0.003, p=0.043, p=0.001, p=0.008), as well for brachial and central diastolic BP for the control condition (p=0.044, p=0.015). Brachial systolic BP at 3-hours-intervention and central systolic BP at 1-hour-intervention were significantly higher for the control condition compared to the Exercise Plus Sitting Plus Standing condition (p=0.005, p=0.010). Conclusions: BP and cfPWV may not be meaningfully influenced by these strategies and do not seem to be related. These strategies may reduce BP in the brachial and aortic arteries, and a combination of prior exercise and intermittent standing may reduce systolic BP more effectively. Future research should explore mechanistic links between sitting and aortic stiffening and experiment with other strategies.
","abstract_html":"<p>Prolonged sitting can cause adverse vascular responses, including elevations in aortic stiffness which might contribute to cardiovascular disease (CVD). Few studies have investigated the impact of intermittent standing and/or prior exercise as strategies to mitigate these deleterious vascular changes. <strong>Purpose:</strong> to explore vascular health responses to prolonged sitting, with and without intermittent standing and/or prior exercise. <strong>Methods: </strong>15 males aged between 18 and 31 years were recruited. Participants completed a control condition (Sitting Only), and three randomized strategy conditions (Sitting Plus Standing, Exercise Plus Sitting, Exercise Plus Sitting Plus Standing). For all conditions, measurements of carotid-femoral PWV (cfPWV) were taken at pre- and post-intervention, and brachial and central blood pressure (BP) at pre-, 1-hour-, 2-hours-, and 3-hours-intervention. <strong>Results: </strong>Condition and time did not interact significantly for any vascular parameters. cfPWV significantly increased from pre- to post-intervention for all conditions (p=0.003, p=0.043, p=0.001, p=0.008), as well for brachial and central diastolic BP for the control condition (p=0.044, p=0.015). Brachial systolic BP at 3-hours-intervention and central systolic BP at 1-hour-intervention were significantly higher for the control condition compared to the Exercise Plus Sitting Plus Standing condition (p=0.005, p=0.010). <strong>Conclusions:</strong> BP and cfPWV may not be meaningfully influenced by these strategies and do not seem to be related. These strategies may reduce BP in the brachial and aortic arteries, and a combination of prior exercise and intermittent standing may reduce systolic BP more effectively. Future research should explore mechanistic links between sitting and aortic stiffening and experiment with other strategies.</p>","abstract_has_math":false,"creators":["Wright, Alexander"],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Masters Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Dr. Stephanie McCoy","Dr. Riley Galloway","Dr. Paul Donahue"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-04-22T07:00:00Z","date_published":"2022-04-22T07:00:00Z","updated_at":"2026-07-24T05:45:33Z","subjects":["Sitting","Aorta","Stiffening","Strategies","Exercise","Standing"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://aquila.usm.edu/masters_theses/910","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dr. Stephanie McCoy","Dr. Riley Galloway","Dr. Paul Donahue"]},{"key":"dc:creator","label":"Author","values":["Wright, Alexander"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2023-07-01T07:00:00Z"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Sitting","Aorta","Stiffening","Strategies","Exercise","Standing"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://aquila.usm.edu/masters_theses/910"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Prolonged sitting can cause adverse vascular responses, including elevations in aortic stiffness which might contribute to cardiovascular disease (CVD). Few studies have investigated the impact of intermittent standing and/or prior exercise as strategies to mitigate these deleterious vascular changes. Purpose: to explore vascular health responses to prolonged sitting, with and without intermittent standing and/or prior exercise. Methods: 15 males aged between 18 and 31 years were recruited. Participants completed a control condition (Sitting Only), and three randomized strategy conditions (Sitting Plus Standing, Exercise Plus Sitting, Exercise Plus Sitting Plus Standing). For all conditions, measurements of carotid-femoral PWV (cfPWV) were taken at pre- and post-intervention, and brachial and central blood pressure (BP) at pre-, 1-hour-, 2-hours-, and 3-hours-intervention. Results: Condition and time did not interact significantly for any vascular parameters. cfPWV significantly increased from pre- to post-intervention for all conditions (p=0.003, p=0.043, p=0.001, p=0.008), as well for brachial and central diastolic BP for the control condition (p=0.044, p=0.015). Brachial systolic BP at 3-hours-intervention and central systolic BP at 1-hour-intervention were significantly higher for the control condition compared to the Exercise Plus Sitting Plus Standing condition (p=0.005, p=0.010). Conclusions: BP and cfPWV may not be meaningfully influenced by these strategies and do not seem to be related. These strategies may reduce BP in the brachial and aortic arteries, and a combination of prior exercise and intermittent standing may reduce systolic BP more effectively. Future research should explore mechanistic links between sitting and aortic stiffening and experiment with other strategies.
"]},{"key":"dc:title","label":"Title","values":["Intermittent Standing and Prior Exercise as Strategies to Prevent Arterial Stiffening That Can Arise From Prolonged Sitting"]}]}],"canonical_facts":{"dc:contributor":["Dr. Stephanie McCoy","Dr. Riley Galloway","Dr. Paul Donahue"],"dc:creator":["Wright, Alexander"],"dc:date.available":["2023-07-01T07:00:00Z"],"dc:description.abstract":["Prolonged sitting can cause adverse vascular responses, including elevations in aortic stiffness which might contribute to cardiovascular disease (CVD). Few studies have investigated the impact of intermittent standing and/or prior exercise as strategies to mitigate these deleterious vascular changes. Purpose: to explore vascular health responses to prolonged sitting, with and without intermittent standing and/or prior exercise. Methods: 15 males aged between 18 and 31 years were recruited. Participants completed a control condition (Sitting Only), and three randomized strategy conditions (Sitting Plus Standing, Exercise Plus Sitting, Exercise Plus Sitting Plus Standing). For all conditions, measurements of carotid-femoral PWV (cfPWV) were taken at pre- and post-intervention, and brachial and central blood pressure (BP) at pre-, 1-hour-, 2-hours-, and 3-hours-intervention. Results: Condition and time did not interact significantly for any vascular parameters. cfPWV significantly increased from pre- to post-intervention for all conditions (p=0.003, p=0.043, p=0.001, p=0.008), as well for brachial and central diastolic BP for the control condition (p=0.044, p=0.015). Brachial systolic BP at 3-hours-intervention and central systolic BP at 1-hour-intervention were significantly higher for the control condition compared to the Exercise Plus Sitting Plus Standing condition (p=0.005, p=0.010). Conclusions: BP and cfPWV may not be meaningfully influenced by these strategies and do not seem to be related. These strategies may reduce BP in the brachial and aortic arteries, and a combination of prior exercise and intermittent standing may reduce systolic BP more effectively. Future research should explore mechanistic links between sitting and aortic stiffening and experiment with other strategies.
"],"dc:identifier":["https://aquila.usm.edu/masters_theses/910"],"dc:subject":["Sitting","Aorta","Stiffening","Strategies","Exercise","Standing"],"dc:title":["Intermittent Standing and Prior Exercise as Strategies to Prevent Arterial Stiffening That Can Arise From Prolonged Sitting"],"thesis:degree_level":["Masters Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T05:45:33Z"}