University of Southern Mississippi
Design, Synthesis, and Characterization of Glycodendrons Through Small Molecule and Linear Polymer Models
Abstract
dc:description.abstract<p>This thesis focuses on the design, synthesis, and characterization of glycopolymer-dendron thiol-ene coupling reactions with the long-term goal of increasing biocompatibility of near infrared (NIR) fluorophores for bioimaging applications. A design of experiments was used with small molecule model compounds to determine the parameters for successful thiol-ene click reactions that would lead to success of more complicated amphipathic polymer-polymer coupling reactions. The first chapter provides an introductory overview of the importance and applications of glycopolymers, bioimaging, and Janus dendrimersomes. The second chapter presents the synthetic methods for creating a glucose-functionalized glycopolymer with an acrylamide backbone, the exploration of thiol-ene coupling reaction conditions for small molecules and glycopolymers/dendrons, and a description of the characterization methods utilized. In chapter three, the effectiveness of the synthetic routes and results from the characterization methods are discussed. Chapter five covers the conclusions of this thesis as well as future work needed to reach the overall goal of creating biocompatible Janus glycodendrimersomes for bioimaging applications.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science (MS)
- Level thesis:degree_level
- Masters Thesis
- Year dc:date.available
- 2021
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Jones, Molly
- Contributors dc:contributor
-
- Dr. Sarah E. Morgan
- Dr. Derek L. Patton
- Dr. Adam E. Smith
Subjects
dc:subject × 5Identifiers
dc:identifier.*- Repository record dc:identifier
- https://aquila.usm.edu/masters_theses/855
- OAI identifier oai:identifier
- oai:aquila.usm.edu:masters_theses-1918