Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu2+ metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could promote a higher density of terminal metal sites. For linkers, the results show that CDI and TESPSA are comparable in functionality, whereas the ligand, lysine-NTA outperforms an amino-functionalized terpyridine in metal chelation. For dendrimers, higher generation dendrimers lead to more terminal Cu2+ metal binding sites than lower generation dendrimers.
","abstract_html":"<p>Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu<sup>2+</sup> metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could promote a higher density of terminal metal sites. For linkers, the results show that CDI and TESPSA are comparable in functionality, whereas the ligand, lysine-NTA outperforms an amino-functionalized terpyridine in metal chelation. For dendrimers, higher generation dendrimers lead to more terminal Cu2+ metal binding sites than lower generation dendrimers.</p>","abstract_has_math":false,"creators":["Dancer, Justin D"],"institution":null,"degree_name":"Master of Science in Chemistry","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Dr. Lawrence Margerum","Dr. William Melaugh","Dr. Ryan West"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-05-16T07:00:00Z","date_published":"2014-05-16T07:00:00Z","updated_at":"2026-07-24T05:43:40Z","subjects":["Chemosensor","CPG","dendrimer","Indicator Displacement Assay","Analytical Chemistry"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repository.usfca.edu/thes/191","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dr. Lawrence Margerum","Dr. William Melaugh","Dr. Ryan West"]},{"key":"dc:creator","label":"Author","values":["Dancer, Justin D"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2016-08-15T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Chemistry"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemosensor","CPG","dendrimer","Indicator Displacement Assay","Analytical Chemistry"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.usfca.edu/thes/191"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu2+ metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could promote a higher density of terminal metal sites. For linkers, the results show that CDI and TESPSA are comparable in functionality, whereas the ligand, lysine-NTA outperforms an amino-functionalized terpyridine in metal chelation. For dendrimers, higher generation dendrimers lead to more terminal Cu2+ metal binding sites than lower generation dendrimers.
"]},{"key":"dc:title","label":"Title","values":["Glass Foundation Chemosensor Synthesis and Functionality Analysis"]}]}],"canonical_facts":{"dc:contributor":["Dr. Lawrence Margerum","Dr. William Melaugh","Dr. Ryan West"],"dc:creator":["Dancer, Justin D"],"dc:date.available":["2016-08-15T07:00:00Z"],"dc:description.abstract":["Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu2+ metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could promote a higher density of terminal metal sites. For linkers, the results show that CDI and TESPSA are comparable in functionality, whereas the ligand, lysine-NTA outperforms an amino-functionalized terpyridine in metal chelation. For dendrimers, higher generation dendrimers lead to more terminal Cu2+ metal binding sites than lower generation dendrimers.
"],"dc:identifier":["https://repository.usfca.edu/thes/191"],"dc:subject":["Chemosensor","CPG","dendrimer","Indicator Displacement Assay","Analytical Chemistry"],"dc:title":["Glass Foundation Chemosensor Synthesis and Functionality Analysis"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science in Chemistry"]},"updated_at":"2026-07-24T05:43:40Z"}