{"id":{"repo_id":"usf","oai_identifier":"oai:digitalcommons.usf.edu:etd-1111"},"canonical_url":"https://search.dev.ndltd.org/etd/usf/oai:digitalcommons.usf.edu:etd-1111","repository":{"repo_id":"usf","name":"University of South Florida","base_url":"https://digitalcommons.usf.edu/do/oai/"},"display":{"title":"Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)","abstract":"Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.","abstract_html":"Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA.","abstract_has_math":false,"creators":["Ajmera, Mehul J"],"institution":"Digital Commons @ University of South Florida","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007-12-03T08:00:00Z","date_published":"2007-12-03T08:00:00Z","updated_at":"2026-07-24T05:42:11Z","subjects":["Antisense","Antigene","Antibacterial","Antiviral","Cytosine acetic acid","American Studies","Arts and Humanities"],"languages":[],"rights":["default"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.usf.edu/etd/112","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ajmera, Mehul J"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2007-12-03T08:00:00Z"]},{"key":"dc:publisher","label":"Institution","values":["Digital Commons @ University of South Florida"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Antisense","Antigene","Antibacterial","Antiviral","Cytosine acetic acid","American Studies","Arts and Humanities"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["default"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.usf.edu/etd/112","https://digitalcommons.usf.edu/context/etd/article/1111/viewcontent/etd__112.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:source","label":"Dc Source","values":["USF Tampa Graduate Theses and Dissertations"]},{"key":"dc:title","label":"Title","values":["Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)"]}]}],"canonical_facts":{"dc:creator":["Ajmera, Mehul J"],"dc:date":["2007-12-03T08:00:00Z"],"dc:description":["Many diseases are caused due to abnormalities in production of specific protein. Across this protein the conventional lock and key mechanism shows binding at the specific cites of protein. However use of antisense technology can prevent formation of protein. It does so by binding to mRNA and prevents transcription. The structural modifications lead to synthetic molecules with 18-mer units which show significant improvement in binding properties, this gives birth to a new class of oligomers called Peptide Nucleic Acid (PNA). We herein report cysteine based PNA called CPNA."],"dc:format":["application/pdf"],"dc:identifier":["https://digitalcommons.usf.edu/etd/112","https://digitalcommons.usf.edu/context/etd/article/1111/viewcontent/etd__112.pdf"],"dc:publisher":["Digital Commons @ University of South Florida"],"dc:rights":["default"],"dc:source":["USF Tampa Graduate Theses and Dissertations"],"dc:subject":["Antisense","Antigene","Antibacterial","Antiviral","Cytosine acetic acid","American Studies","Arts and Humanities"],"dc:title":["Synthesis of Novel Cysteine Peptide Nucleic Acid (CPNA)"],"dc:type":["thesis"]},"updated_at":"2026-07-24T05:42:11Z"}