Oxygen Consumption in Sepsis

<p>Background: Sepsis is a life-threatening condition that can lead to septic shock and death. With over 300,000 annual cases (AHRQ, 2011) costing a staggering $1.5 billion (Health Care Utilization Project Brief #185), the importance of sepsis is becoming clear. However, some basic biological mechanisms are poorly understood. Study Purpose: This study investigated the relationships between select demographics, resting energy expenditure (REE), serum lactate, SOFA score mortality index, oxygen consumption [by way of measuring net oxygen consumed, (V02) and net carbon dioxide produced (VC02)], and sepsis. Specific Aims: Aims were to describe 1) patient demographics, serum lactate, SOFA score mortality index, sepsis diagnosis, and 02 consumption; 2) the difference in oxygen consumption in ICU patients with and without a diagnosis of sepsis; 3a) the relationships between gender, age, REE, height, weight, lactate and VO2; 3b) the relationships between gender, age, REE, height, weight, lactate and VCO2; and 4) the relationships between age, gender, height, weight, VO2, VCO2, lactate, SOFA, REE, and sepsis Methods: Data for this quantitative descriptive feasibility study were accessed from two hospital databases. Results: For the total cases (N = 21) mean age was 71.2 years (+/- 14.1) and mostly female (71.4%). There was a difference in oxygen consumption between the two groups of cases (sepsis and non-sepsis) [VO2 (t 3.919, p 0.001), VC02 (η = 608, p = 0.003), and lactate (η = 621, p = 0.003). Implications: Nurses are at the forefront of monitoring patients with sepsis. While this study utilized a small sample size, significant relationships were found among a number of important clinical variables. Further research is needed utilizing larger samples to test predictive models for sepsis so that nurses can intervene to prevent the deterioration of these patients.</p>

Name thesis:degree_name

PhD Nursing

Level thesis:degree_level

Dissertation: Open Access

Discipline thesis:degree_discipline

Nursing

Year dc:date.available

2018

Author dc:creator

• Graham, Julie

• mitochondrial dysfunction
• cytopathic hypoxia
• sepsis
• oxygen consumption
• serum lactate
• SOFA
• Critical Care Nursing
• Medicine and Health Sciences

Repository record dc:identifier

https://digital.sandiego.edu/dissertations/121

OAI identifier oai:identifier

oai:digital.sandiego.edu:dissertations-1122