The Association of Kangaroo Mother Care, Energy Conservation, and Bonding in Preterm Neonates
type: CreativeWork
description: Purpose:To examine the association of kangaroo mother care (KMC) on energy utilization and bonding as evidenced by reduced biochemical markers of adenosine triphosphate (ATP) degradation, hypoxanthine (Hx), xanthine (Xa), and uric acid (UA), and (allantoin), a measure of oxidative stress in preterm infants 24-36 weeks gestation. A secondary objective was to compare specific physiological parameters using bedside monitoring and perfusion and oxygenation of the gut using near-infrared spectroscopy (NIRS) during 1 hour of KMC compared to incubator care. Study design: A randomized controlled trial (RCT) examining the effects of 1-hour of KMC or 1-hour incubator care on urinary markers from samples collected 3-6 hrs before, and 3-6 hours after KMC. Preterm infants (n = 51) were assigned to intervention/control groups using stratified randomization based on weight. Urine concentrations of Hx, Xa, and UA were measured using high performance liquid chromatography (HPLC) and allantoin was quantified using gas chromatography-mass spectrometry (GC-MS) methods. Bonding was measured using the Mother-to-infant Bonding Scale, a reliable 8-item self-assessment scale linking early maternal moods to difficulties in bonding. Psychometric properties have demonstrated a two-factor model, good predictive validity, a sensitivity of 0.90 and specificity of 0.80 for a threshold score ≥ 2, and acceptable internal consistency (a= 0.71). Physiologic measures were captured using bedside monitoring and abdominal NIRS to capture gut perfusion and oxygenation. Results: There was a decrease in oxidative stress (p= 0.026) in the KMC group compared to incubator group.In both groups there were trending improvement in uric acid (p = 0.025) and xanthine (p= 0.042) over time, and in abdominal temperatures (p = 0.004) and perfusion index (p = 0.031) over time. No other physiologic or urinary measures showed statistically significant changes either between the groups or over time. A mixed model analysis of…
abstract: Purpose:To examine the association of kangaroo mother care (KMC) on energy utilization and bonding as evidenced by reduced biochemical markers of adenosine triphosphate (ATP) degradation, hypoxanthine (Hx), xanthine (Xa), and uric acid (UA), and (allantoin), a measure of oxidative stress in preterm infants 24-36 weeks gestation. A secondary objective was to compare specific physiological parameters using bedside monitoring and perfusion and oxygenation of the gut using near-infrared spectroscopy (NIRS) during 1 hour of KMC compared to incubator care. Study design: A randomized controlled trial (RCT) examining the effects of 1-hour of KMC or 1-hour incubator care on urinary markers from samples collected 3-6 hrs before, and 3-6 hours after KMC. Preterm infants (n = 51) were assigned to intervention/control groups using stratified randomization based on weight. Urine concentrations of Hx, Xa, and UA were measured using high performance liquid chromatography (HPLC) and allantoin was quantified using gas chromatography-mass spectrometry (GC-MS) methods. Bonding was measured using the Mother-to-infant Bonding Scale, a reliable 8-item self-assessment scale linking early maternal moods to difficulties in bonding. Psychometric properties have demonstrated a two-factor model, good predictive validity, a sensitivity of 0.90 and specificity of 0.80 for a threshold score ≥ 2, and acceptable internal consistency (a= 0.71). Physiologic measures were captured using bedside monitoring and abdominal NIRS to capture gut perfusion and oxygenation. Results: There was a decrease in oxidative stress (p= 0.026) in the KMC group compared to incubator group.In both groups there were trending improvement in uric acid (p = 0.025) and xanthine (p= 0.042) over time, and in abdominal temperatures (p = 0.004) and perfusion index (p = 0.031) over time. No other physiologic or urinary measures showed statistically significant changes either between the groups or over time. A mixed model analysis of…
author: Forde, Dorothy
keywords: biochemical markers, energy conservation, Kangaroo Mother Care (KMC), preterm neonates, prematurity, decreased morbidity, ATP degradation, Hypoxanthine, Xanthine, Uric acid, allantoin (oxidative stress) Abdominal Near-Infrared spectroscopy, abdominal temperatures, skin-to-skin care, Biochemical Phenomena, Metabolism, and Nutrition, Critical Care Nursing, Maternal, Child Health and Neonatal Nursing, Medical Biochemistry, Physiological Processes, Translational Medical Research
date published: 2018-05-26T07:00:00Z
date modified: 2026-07-24T05:41:35Z
provider: University of San Diego
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of San Diego