{"id":{"repo_id":"uoit","oai_identifier":"oai:ontariotechu.scholaris.ca:10155/981"},"canonical_url":"https://search.dev.ndltd.org/etd/uoit/oai:ontariotechu.scholaris.ca:10155/981","repository":{"repo_id":"uoit","name":"Ontario Institute of Technology","base_url":"https://ontariotechu.scholaris.ca/server/oai/request"},"display":{"title":"Depletant induced attractions in red blood cells","abstract":"Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau remains underexplored. This thesis employs coarse-grained molecular simulations to model erythrocytes in a disperse limit subject to short range implicit depletion forces. This work demonstrates that the depletant interaction is sufficient to account for sudden transitions into aggregate states. Furthermore, this work demonstrates that the specific volume fraction of depletants is directly linked to the morphologies of the aggregate states observed.","abstract_html":"Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau remains underexplored. This thesis employs coarse-grained molecular simulations to model erythrocytes in a disperse limit subject to short range implicit depletion forces. This work demonstrates that the depletant interaction is sufficient to account for sudden transitions into aggregate states. Furthermore, this work demonstrates that the specific volume fraction of depletants is directly linked to the morphologies of the aggregate states observed.","abstract_has_math":false,"creators":["Nehring, Austin"],"institution":"University of Ontario Institute of Technology","degree_name":"Master of Science (MSc)","degree_level":null,"degree_discipline":"Materials Science","degree_department":null,"school":null,"contributors":[],"advisors":["de Haan, Hendrick"],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-01","date_published":"2018-10-01","updated_at":"2026-07-24T05:35:22Z","subjects":["Bio-physics","Simulation","Coarse-grained","Molecular dynamics","Rouleau"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10155/981","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["de Haan, Hendrick"]},{"key":"dc:creator","label":"Author","values":["Nehring, Austin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-11-02T15:09:51Z","2022-03-29T17:25:49Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-11-02T15:09:51Z","2022-03-29T17:25:49Z"]},{"key":"dc:date.issued","label":"Date","values":["2018-10-01"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Ontario Institute of Technology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bio-physics","Simulation","Coarse-grained","Molecular dynamics","Rouleau"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10155/981"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau remains underexplored. This thesis employs coarse-grained molecular simulations to model erythrocytes in a disperse limit subject to short range implicit depletion forces. This work demonstrates that the depletant interaction is sufficient to account for sudden transitions into aggregate states. Furthermore, this work demonstrates that the specific volume fraction of depletants is directly linked to the morphologies of the aggregate states observed."]},{"key":"dc:title","label":"Title","values":["Depletant induced attractions in red blood cells"]}]}],"canonical_facts":{"dc:contributor.advisor":["de Haan, Hendrick"],"dc:creator":["Nehring, Austin"],"dc:date.accessioned":["2018-11-02T15:09:51Z","2022-03-29T17:25:49Z"],"dc:date.available":["2018-11-02T15:09:51Z","2022-03-29T17:25:49Z"],"dc:date.issued":["2018-10-01"],"dc:description.abstract":["Red blood cells suspended in plasma are able to aggregate into linearly stacked rouleau. The aggregations can form complex clusters and branching networks which cause complications in various pathological cases. The self assembly and biophysics behind the aggregation of red blood cells into rouleau remains underexplored. This thesis employs coarse-grained molecular simulations to model erythrocytes in a disperse limit subject to short range implicit depletion forces. This work demonstrates that the depletant interaction is sufficient to account for sudden transitions into aggregate states. Furthermore, this work demonstrates that the specific volume fraction of depletants is directly linked to the morphologies of the aggregate states observed."],"dc:identifier.uri":["https://hdl.handle.net/10155/981"],"dc:language.iso":["en"],"dc:subject":["Bio-physics","Simulation","Coarse-grained","Molecular dynamics","Rouleau"],"dc:title":["Depletant induced attractions in red blood cells"],"dc:type":["Thesis"],"thesis:degree_discipline":["Materials Science"],"thesis:degree_name":["Master of Science (MSc)"],"thesis:institution_name":["University of Ontario Institute of Technology"]},"updated_at":"2026-07-24T05:35:22Z"}