Modelling the movement of superparamagnetic beads engulfed in endothelial cells

Colonization of porous scaffolds with cells is of increasing importance for various tissue engineering applications. Controlled placement of human umbilical vein endothelial cells (HUVECs) within a micro-porous, poly-caprolactone scaffold is facilitated with superparamagnetic beads introduced to the cells by phagocytosis. It is shown that the dominant motion of the affected cells is determined by the viscous drag of the medium and the amount of coupling with an externally imposed magnetic field. An efficient numerical scheme to compute the trajectories of the cells is presented as the first step in the optimal placement of a large collections of cells with varying numbers of embedded beads.

Name thesis:degree_name

Master of Science (MSc)

Discipline thesis:degree_discipline

Modelling and Computational Science

Grantor

University of Ontario Institute of Technology

Year dc:date.issued

2018

Author dc:creator

• Pasut, Daniel

Advisor dc:contributor.advisor

• Bohun, Sean

• Superparamagnetic beads
• Magnetic fields
• Numerical scheme
• Tissue engineering

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/10155/961

OAI identifier oai:identifier

oai:ontariotechu.scholaris.ca:10155/961