{"id":{"repo_id":"uoit","oai_identifier":"oai:ontariotechu.scholaris.ca:10155/1499"},"canonical_url":"https://search.dev.ndltd.org/etd/uoit/oai:ontariotechu.scholaris.ca:10155/1499","repository":{"repo_id":"uoit","name":"Ontario Institute of Technology","base_url":"https://ontariotechu.scholaris.ca/server/oai/request"},"display":{"title":"Response of salivary IL-8 to prolonged and interrupted sitting","abstract":"The effect of prolonged sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of walking). Saliva and capillary plasma samples were collected pre- and post-session. Weekly variability in salivary IL-8 and individual responses were also explored. Prolonged sitting increased salivary IL-8 concentrations, while interrupted sitting attenuated this response. Among males, there was no increase in salivary IL-8 during interrupted sitting. Prolonged sitting may serve as a pro-inflammatory stimulus, and movement interruptions may negate this response. Saliva sampling seems to be a reliable method in assessing IL-8 across timepoints within individuals; however, there is high variability across individuals.","abstract_html":"The effect of prolonged sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of walking). Saliva and capillary plasma samples were collected pre- and post-session. Weekly variability in salivary IL-8 and individual responses were also explored. Prolonged sitting increased salivary IL-8 concentrations, while interrupted sitting attenuated this response. Among males, there was no increase in salivary IL-8 during interrupted sitting. Prolonged sitting may serve as a pro-inflammatory stimulus, and movement interruptions may negate this response. Saliva sampling seems to be a reliable method in assessing IL-8 across timepoints within individuals; however, there is high variability across individuals.","abstract_has_math":false,"creators":["O’Rourke, Nicholas"],"institution":"University of Ontario Institute of Technology","degree_name":"Master of Health Sciences (MHSc)","degree_level":null,"degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":[],"advisors":["Dogra, Shilpa"],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-08-01","date_published":"2022-08-01","updated_at":"2026-07-24T05:35:38Z","subjects":["Sedentary behaviour","Inflammation","Cytokines","Interleukin 8","Sitting"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10155/1499","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Dogra, Shilpa"]},{"key":"dc:creator","label":"Author","values":["O’Rourke, Nicholas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-08-29T19:31:56Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-08-29T19:31:56Z"]},{"key":"dc:date.issued","label":"Date","values":["2022-08-01"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Health Sciences (MHSc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Ontario Institute of Technology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Sedentary behaviour","Inflammation","Cytokines","Interleukin 8","Sitting"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10155/1499"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The effect of prolonged sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of walking). Saliva and capillary plasma samples were collected pre- and post-session. Weekly variability in salivary IL-8 and individual responses were also explored. Prolonged sitting increased salivary IL-8 concentrations, while interrupted sitting attenuated this response. Among males, there was no increase in salivary IL-8 during interrupted sitting. Prolonged sitting may serve as a pro-inflammatory stimulus, and movement interruptions may negate this response. Saliva sampling seems to be a reliable method in assessing IL-8 across timepoints within individuals; however, there is high variability across individuals."]},{"key":"dc:title","label":"Title","values":["Response of salivary IL-8 to prolonged and interrupted sitting"]}]}],"canonical_facts":{"dc:contributor.advisor":["Dogra, Shilpa"],"dc:creator":["O’Rourke, Nicholas"],"dc:date.accessioned":["2022-08-29T19:31:56Z"],"dc:date.available":["2022-08-29T19:31:56Z"],"dc:date.issued":["2022-08-01"],"dc:description.abstract":["The effect of prolonged sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of walking). Saliva and capillary plasma samples were collected pre- and post-session. Weekly variability in salivary IL-8 and individual responses were also explored. Prolonged sitting increased salivary IL-8 concentrations, while interrupted sitting attenuated this response. Among males, there was no increase in salivary IL-8 during interrupted sitting. Prolonged sitting may serve as a pro-inflammatory stimulus, and movement interruptions may negate this response. Saliva sampling seems to be a reliable method in assessing IL-8 across timepoints within individuals; however, there is high variability across individuals."],"dc:identifier.uri":["https://hdl.handle.net/10155/1499"],"dc:language.iso":["en"],"dc:subject":["Sedentary behaviour","Inflammation","Cytokines","Interleukin 8","Sitting"],"dc:title":["Response of salivary IL-8 to prolonged and interrupted sitting"],"dc:type":["Thesis"],"thesis:degree_discipline":["Kinesiology"],"thesis:degree_name":["Master of Health Sciences (MHSc)"],"thesis:institution_name":["University of Ontario Institute of Technology"]},"updated_at":"2026-07-24T05:35:38Z"}