{"id":{"repo_id":"uoit","oai_identifier":"oai:ontariotechu.scholaris.ca:10155/1045"},"canonical_url":"https://search.dev.ndltd.org/etd/uoit/oai:ontariotechu.scholaris.ca:10155/1045","repository":{"repo_id":"uoit","name":"Ontario Institute of Technology","base_url":"https://ontariotechu.scholaris.ca/server/oai/request"},"display":{"title":"Active transport and concentration of analytes in microfluidic paper based analytical devices using ion concentration polarization","abstract":"Microfluidic paper-based analytical devices (µPADs) have a high potential for miniaturizing complex testing functions, since they are inexpensive, disposable, and portable. Paper has the advantage over traditional fluid channel systems in that it houses capillary-driven flow, which requires no external pumps or equipment. However, these paper-based devices have one disadvantage in that they do not enable further flow of fluids after becoming fully wet. In this work, active transport and concentration of analytes in fully wet paper-based assays is demonstrated by leveraging ion concentration polarization (ICP). The efficacy of ICP-inducing µPADs is demonstrated through transporting and concentrating dye, fluorescein and immunoglobulins. The application of actively concentrating immunoglobulins - antibodies with sample concentrations that are typically below traditional limits of detection - is a novel application of ICP and can be used to create universally accessible allergy tests.","abstract_html":"Microfluidic paper-based analytical devices (µPADs) have a high potential for miniaturizing complex testing functions, since they are inexpensive, disposable, and portable. Paper has the advantage over traditional fluid channel systems in that it houses capillary-driven flow, which requires no external pumps or equipment. However, these paper-based devices have one disadvantage in that they do not enable further flow of fluids after becoming fully wet. In this work, active transport and concentration of analytes in fully wet paper-based assays is demonstrated by leveraging ion concentration polarization (ICP). The efficacy of ICP-inducing µPADs is demonstrated through transporting and concentrating dye, fluorescein and immunoglobulins. The application of actively concentrating immunoglobulins - antibodies with sample concentrations that are typically below traditional limits of detection - is a novel application of ICP and can be used to create universally accessible allergy tests.","abstract_has_math":false,"creators":["Crowley, Michael"],"institution":"University of Ontario Institute of Technology","degree_name":"Master of Applied Science (MASc)","degree_level":null,"degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":["MacDonald, Brendan"],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-01","date_published":"2019-04-01","updated_at":"2026-07-24T05:35:30Z","subjects":["Microfluidics","Paper-based","Analyte Transport","Concentration","Allergy test"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10155/1045","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["MacDonald, Brendan"]},{"key":"dc:creator","label":"Author","values":["Crowley, Michael"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-05-02T20:31:51Z","2022-03-29T16:46:13Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2019-05-02T20:31:51Z","2022-03-29T16:46:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2019-04-01"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Applied Science (MASc)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Ontario Institute of Technology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Microfluidics","Paper-based","Analyte Transport","Concentration","Allergy test"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10155/1045"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Microfluidic paper-based analytical devices (µPADs) have a high potential for miniaturizing complex testing functions, since they are inexpensive, disposable, and portable. Paper has the advantage over traditional fluid channel systems in that it houses capillary-driven flow, which requires no external pumps or equipment. However, these paper-based devices have one disadvantage in that they do not enable further flow of fluids after becoming fully wet. In this work, active transport and concentration of analytes in fully wet paper-based assays is demonstrated by leveraging ion concentration polarization (ICP). The efficacy of ICP-inducing µPADs is demonstrated through transporting and concentrating dye, fluorescein and immunoglobulins. The application of actively concentrating immunoglobulins - antibodies with sample concentrations that are typically below traditional limits of detection - is a novel application of ICP and can be used to create universally accessible allergy tests."]},{"key":"dc:title","label":"Title","values":["Active transport and concentration of analytes in microfluidic paper based analytical devices using ion concentration polarization"]}]}],"canonical_facts":{"dc:contributor.advisor":["MacDonald, Brendan"],"dc:creator":["Crowley, Michael"],"dc:date.accessioned":["2019-05-02T20:31:51Z","2022-03-29T16:46:13Z"],"dc:date.available":["2019-05-02T20:31:51Z","2022-03-29T16:46:13Z"],"dc:date.issued":["2019-04-01"],"dc:description.abstract":["Microfluidic paper-based analytical devices (µPADs) have a high potential for miniaturizing complex testing functions, since they are inexpensive, disposable, and portable. Paper has the advantage over traditional fluid channel systems in that it houses capillary-driven flow, which requires no external pumps or equipment. However, these paper-based devices have one disadvantage in that they do not enable further flow of fluids after becoming fully wet. In this work, active transport and concentration of analytes in fully wet paper-based assays is demonstrated by leveraging ion concentration polarization (ICP). The efficacy of ICP-inducing µPADs is demonstrated through transporting and concentrating dye, fluorescein and immunoglobulins. The application of actively concentrating immunoglobulins - antibodies with sample concentrations that are typically below traditional limits of detection - is a novel application of ICP and can be used to create universally accessible allergy tests."],"dc:identifier.uri":["https://hdl.handle.net/10155/1045"],"dc:language.iso":["en"],"dc:subject":["Microfluidics","Paper-based","Analyte Transport","Concentration","Allergy test"],"dc:title":["Active transport and concentration of analytes in microfluidic paper based analytical devices using ion concentration polarization"],"dc:type":["Thesis"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_name":["Master of Applied Science (MASc)"],"thesis:institution_name":["University of Ontario Institute of Technology"]},"updated_at":"2026-07-24T05:35:30Z"}