Effect of Chronic Alcohol Abuse and Resistance Training on the Skeletal Muscle Androgen Receptor Concentration of Rats

The purpose was to examine the effect of chronic alcohol abuse on the androgen receptor content (AR) in skeletal muscle, and to determine if this effect was influenced by resistance training. Thirty-four male rats (456 ± 1 g; mean ± SE) were divided into 4 groups: Sham exercise-Ethanol, Sham exercise-Normal diet, Exercise-Ethanol, and Exercise-Normal diet. Both Exercise groups underwent a 6-week "squat" resistance training protocol and both Ethanol groups received an alcohol-rich diet throughout the 6-week period. Western blot analysis showed no effect of alcohol or resistance training on the AR of the extensor digitorum longus. For the rectus femoris, alcohol caused a decline in the AR (p=0.01). This reduction was not attenuated by resistance training. The AR of the soleus was not affected by chronic alcohol abuse alone; however, the resistance training induced increase in the AR was prevented by chronic alcohol abuse (p=0.03).

Grantor dc:publisher

University of North Texas

Year dc:date

2004

Author dc:creator

• Vingren, Jakob L.

Contributors dc:contributor

• Koziris, L. Perry
• Jackson, Allen
• Hill, David W.

• Alcohol -- Physiological effect.
• Androgens -- Receptors.
• Rats -- Nervous system.
• ethanol
• androgen
• testosterone
• exercise
• weight training

Statement dc:rights

• Use restricted to UNT Community
• Copyright
• Vingren, Jakob L.
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 56698761
https://digital.library.unt.edu/ark:/67531/metadc4540/
ark: ark:/67531/metadc4540

OAI identifier oai:identifier

info:ark/67531/metadc4540