Computational Studies on Group 14 Elements (C, Si and Ge) in Organometallic and Biological Compounds.

A series of computational studies were carried out on Group 14 (C, Si and Ge) elements in organometallic and biological compounds. Theoretical studies on classical and H-bridged A3H3+ (A=C, Si and Ge) as p ligands with different organometallic fragments at B3LYP and B3P86 level reveal a reverse charge transfer from ligand to metal in Si and Ge complexes whereas in C complexes there is a small charge transfer from metal to ligand. The H-bridged complexes are more stable than the complexes based on Si3H3+ and Ge3H3+ ligands with terminal hydrogens. The stability of the bridged systems increases from Si to Ge. Corrective scale factors for computed harmonic CºO vibrational frequencies for 31 organometallic complexes have been determined at the HF and B3LYP levels. The scaled B3LYP frequencies exhibit a greater reliability than do HF frequencies. Experimental data have shown that Si/Ge-substituted decapeptides are advantageous over their C analog in vitro and in vivo studies in modern hormone therapy. A computational investigation was carried out on the synthesized decapeptides focusing on position 5 containing Si and Ge. The results have shown that there are some differences in C, Si and Ge-containing analogs. However, further investigations are needed to elucidate the observed advantages of Si/Ge over C analogs.

Grantor dc:publisher

University of North Texas

Year dc:date

2007

Author dc:creator

• Yu, Liwen

Contributors dc:contributor

• Schwartz, Martin
• Marshall, Paul, 1960-
• Cundari, Thomas R.
• Omary, Mohammad
• Poirier, Bill

• computational investigation
• organometallics
• Group 14
• charge transfer
• Group 14 elements.
• Organometallic compounds.
• Biochemistry.

Statement dc:rights

• Public
• Copyright
• Yu, Liwen
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 180909560
https://digital.library.unt.edu/ark:/67531/metadc3591/
ark: ark:/67531/metadc3591

OAI identifier oai:identifier

info:ark/67531/metadc3591