{"id":{"repo_id":"unr","oai_identifier":"oai:scholarwolf.unr.edu:11714/609"},"canonical_url":"https://search.dev.ndltd.org/etd/unr/oai:scholarwolf.unr.edu:11714/609","repository":{"repo_id":"unr","name":"University of Nevada - Reno","base_url":"https://scholarwolf.unr.edu/server/oai/request"},"display":{"title":"Guidance of Developing Motor Neurons into the Periphery","abstract":"Motor neurons (MNs) are a diverse class of cells that originate in the central nervous system and project to muscles in the periphery. The development of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. Molecular cues have been attributed to the organization of MNs into columns within the spinal cord and then into specific motor pools. These cues have also been shown to be responsible for axon guidance into the periphery and important for axons to innervate the correct targets. Despite advances in research on specific guidance cues used by different subdivisions of MNs, it is still not fully understood how signaling systems work with one another in the same environment to guide different classes of MNs to their respective muscle targets.","abstract_html":"Motor neurons (MNs) are a diverse class of cells that originate in the central nervous system and project to muscles in the periphery. The development of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. Molecular cues have been attributed to the organization of MNs into columns within the spinal cord and then into specific motor pools. These cues have also been shown to be responsible for axon guidance into the periphery and important for axons to innervate the correct targets. Despite advances in research on specific guidance cues used by different subdivisions of MNs, it is still not fully understood how signaling systems work with one another in the same environment to guide different classes of MNs to their respective muscle targets.","abstract_has_math":false,"creators":["Kelley, Melissa A."],"institution":"University of Nevada, Reno","degree_name":"Neuroscience","degree_level":"Honors Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Mastick, Grant S."],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-27T21:47:58Z","subjects":[],"languages":["en_US","English"],"rights":["In Copyright(All Rights Reserved)"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11714/609","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Mastick, Grant S."]},{"key":"dc:creator","label":"Author","values":["Kelley, Melissa A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-01-24T23:09:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-01-24T23:09:15Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Honors Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Neuroscience"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Nevada, Reno"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright(All Rights Reserved)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11714/609"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."]},{"key":"dc:description.abstract","label":"Abstract","values":["Motor neurons (MNs) are a diverse class of cells that originate in the central nervous system and project to muscles in the periphery. The development of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. Molecular cues have been attributed to the organization of MNs into columns within the spinal cord and then into specific motor pools. These cues have also been shown to be responsible for axon guidance into the periphery and important for axons to innervate the correct targets. Despite advances in research on specific guidance cues used by different subdivisions of MNs, it is still not fully understood how signaling systems work with one another in the same environment to guide different classes of MNs to their respective muscle targets."]},{"key":"dc:format","label":"Dc Format","values":["PDF"]},{"key":"dc:title","label":"Title","values":["Guidance of Developing Motor Neurons into the Periphery"]}]}],"canonical_facts":{"dc:contributor.advisor":["Mastick, Grant S."],"dc:creator":["Kelley, Melissa A."],"dc:date.accessioned":["2017-01-24T23:09:15Z"],"dc:date.available":["2017-01-24T23:09:15Z"],"dc:date.issued":["2014"],"dc:description":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."],"dc:description.abstract":["Motor neurons (MNs) are a diverse class of cells that originate in the central nervous system and project to muscles in the periphery. The development of all MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. Molecular cues have been attributed to the organization of MNs into columns within the spinal cord and then into specific motor pools. These cues have also been shown to be responsible for axon guidance into the periphery and important for axons to innervate the correct targets. Despite advances in research on specific guidance cues used by different subdivisions of MNs, it is still not fully understood how signaling systems work with one another in the same environment to guide different classes of MNs to their respective muscle targets."],"dc:format":["PDF"],"dc:identifier.uri":["http://hdl.handle.net/11714/609"],"dc:language":["English"],"dc:language.iso":["en_US"],"dc:rights":["In Copyright(All Rights Reserved)"],"dc:title":["Guidance of Developing Motor Neurons into the Periphery"],"dc:type":["Thesis"],"thesis:degree_level":["Honors Thesis"],"thesis:degree_name":["Neuroscience"],"thesis:institution_name":["University of Nevada, Reno"]},"updated_at":"2026-07-27T21:47:58Z"}