{"id":{"repo_id":"unr","oai_identifier":"oai:scholarwolf.unr.edu:11714/555"},"canonical_url":"https://search.dev.ndltd.org/etd/unr/oai:scholarwolf.unr.edu:11714/555","repository":{"repo_id":"unr","name":"University of Nevada - Reno","base_url":"https://scholarwolf.unr.edu/server/oai/request"},"display":{"title":"Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1","abstract":"M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed that HIV-1 replication was reduced in infected M/M when treated with M40401. Our goal is to synthesize M40403, a similar molecule, as well as other related molecules for further study. M40403 and previously synthesized related molecules have been shown to have anti-HIV properties. We will synthesize more related molecules in an attempt to maximize the ratio of potency to toxicity. Hopefully by tweaking the molecules, we will find one that can eventually be made into a drug to help the fight against HIV-1.","abstract_html":"M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed that HIV-1 replication was reduced in infected M/M when treated with M40401. Our goal is to synthesize M40403, a similar molecule, as well as other related molecules for further study. M40403 and previously synthesized related molecules have been shown to have anti-HIV properties. We will synthesize more related molecules in an attempt to maximize the ratio of potency to toxicity. Hopefully by tweaking the molecules, we will find one that can eventually be made into a drug to help the fight against HIV-1.","abstract_has_math":false,"creators":["Pearce, Alexandra R."],"institution":"University of Nevada, Reno","degree_name":"Chemistry","degree_level":"Honors Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Bell, Thomas W."],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-27T21:47:03Z","subjects":[],"languages":["en_US","English"],"rights":["In Copyright(All Rights Reserved)"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11714/555","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Bell, Thomas W."]},{"key":"dc:creator","label":"Author","values":["Pearce, Alexandra R."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-01-24T23:09:10Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-01-24T23:09:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Honors Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Chemistry","Mathematics"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Nevada, Reno"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright(All Rights Reserved)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11714/555"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."]},{"key":"dc:description.abstract","label":"Abstract","values":["M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed that HIV-1 replication was reduced in infected M/M when treated with M40401. Our goal is to synthesize M40403, a similar molecule, as well as other related molecules for further study. M40403 and previously synthesized related molecules have been shown to have anti-HIV properties. We will synthesize more related molecules in an attempt to maximize the ratio of potency to toxicity. Hopefully by tweaking the molecules, we will find one that can eventually be made into a drug to help the fight against HIV-1."]},{"key":"dc:format","label":"Dc Format","values":["PDF"]},{"key":"dc:title","label":"Title","values":["Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1"]}]}],"canonical_facts":{"dc:contributor.advisor":["Bell, Thomas W."],"dc:creator":["Pearce, Alexandra R."],"dc:date.accessioned":["2017-01-24T23:09:10Z"],"dc:date.available":["2017-01-24T23:09:10Z"],"dc:date.issued":["2012"],"dc:description":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."],"dc:description.abstract":["M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed that HIV-1 replication was reduced in infected M/M when treated with M40401. Our goal is to synthesize M40403, a similar molecule, as well as other related molecules for further study. M40403 and previously synthesized related molecules have been shown to have anti-HIV properties. We will synthesize more related molecules in an attempt to maximize the ratio of potency to toxicity. Hopefully by tweaking the molecules, we will find one that can eventually be made into a drug to help the fight against HIV-1."],"dc:format":["PDF"],"dc:identifier.uri":["http://hdl.handle.net/11714/555"],"dc:language":["English"],"dc:language.iso":["en_US"],"dc:rights":["In Copyright(All Rights Reserved)"],"dc:title":["Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1"],"dc:type":["Thesis"],"thesis:degree_level":["Honors Thesis"],"thesis:degree_name":["Chemistry","Mathematics"],"thesis:institution_name":["University of Nevada, Reno"]},"updated_at":"2026-07-27T21:47:03Z"}