{"id":{"repo_id":"unr","oai_identifier":"oai:scholarwolf.unr.edu:11714/3326"},"canonical_url":"https://search.dev.ndltd.org/etd/unr/oai:scholarwolf.unr.edu:11714/3326","repository":{"repo_id":"unr","name":"University of Nevada - Reno","base_url":"https://scholarwolf.unr.edu/server/oai/request"},"display":{"title":"Active Insulin Analogs That Do Not Require Refrigeration","abstract":"Due primarily to hydrophobic interactions between nonpolar amino acid residues, molecules of insulin tend to interact with each other and undergo fibrillation to form linear aggregates when partially unfolded. Formation of these insulin fibrils significantly decreases insulin stability and activity, and has complicated insulin's role in the therapy of diabetes. This study will investigate techniques to create bioactive insulin analogs that are not susceptible to fibrillation, a temperature sensitive process, and thus do not require refrigeration. Solid phase peptide synthesis techniques and the incorporation of backbone modified amino acids into peptide sequences will be used to design novel insulin analogs.","abstract_html":"Due primarily to hydrophobic interactions between nonpolar amino acid residues, molecules of insulin tend to interact with each other and undergo fibrillation to form linear aggregates when partially unfolded. Formation of these insulin fibrils significantly decreases insulin stability and activity, and has complicated insulin's role in the therapy of diabetes. This study will investigate techniques to create bioactive insulin analogs that are not susceptible to fibrillation, a temperature sensitive process, and thus do not require refrigeration. Solid phase peptide synthesis techniques and the incorporation of backbone modified amino acids into peptide sequences will be used to design novel insulin analogs.","abstract_has_math":false,"creators":["Suri, Reba"],"institution":"University of Nevada, Reno","degree_name":"Molecular Microbiology and Immunology","degree_level":"Honors Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Tal-Gan, Yftah"],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T21:45:34Z","subjects":[],"languages":["en_US","English"],"rights":["In Copyright"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11714/3326","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Tal-Gan, Yftah"]},{"key":"dc:creator","label":"Author","values":["Suri, Reba"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-07T17:02:49Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-07T17:02:49Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Honors Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Molecular Microbiology and Immunology"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Nevada, Reno"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11714/3326"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."]},{"key":"dc:description.abstract","label":"Abstract","values":["Due primarily to hydrophobic interactions between nonpolar amino acid residues, molecules of insulin tend to interact with each other and undergo fibrillation to form linear aggregates when partially unfolded. Formation of these insulin fibrils significantly decreases insulin stability and activity, and has complicated insulin's role in the therapy of diabetes. This study will investigate techniques to create bioactive insulin analogs that are not susceptible to fibrillation, a temperature sensitive process, and thus do not require refrigeration. Solid phase peptide synthesis techniques and the incorporation of backbone modified amino acids into peptide sequences will be used to design novel insulin analogs."]},{"key":"dc:format","label":"Dc Format","values":["PDF"]},{"key":"dc:title","label":"Title","values":["Active Insulin Analogs That Do Not Require Refrigeration"]}]}],"canonical_facts":{"dc:contributor.advisor":["Tal-Gan, Yftah"],"dc:creator":["Suri, Reba"],"dc:date.accessioned":["2018-05-07T17:02:49Z"],"dc:date.available":["2018-05-07T17:02:49Z"],"dc:date.issued":["2016"],"dc:description":["The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint."],"dc:description.abstract":["Due primarily to hydrophobic interactions between nonpolar amino acid residues, molecules of insulin tend to interact with each other and undergo fibrillation to form linear aggregates when partially unfolded. Formation of these insulin fibrils significantly decreases insulin stability and activity, and has complicated insulin's role in the therapy of diabetes. This study will investigate techniques to create bioactive insulin analogs that are not susceptible to fibrillation, a temperature sensitive process, and thus do not require refrigeration. Solid phase peptide synthesis techniques and the incorporation of backbone modified amino acids into peptide sequences will be used to design novel insulin analogs."],"dc:format":["PDF"],"dc:identifier.uri":["http://hdl.handle.net/11714/3326"],"dc:language":["English"],"dc:language.iso":["en_US"],"dc:rights":["In Copyright"],"dc:title":["Active Insulin Analogs That Do Not Require Refrigeration"],"dc:type":["Thesis"],"thesis:degree_level":["Honors Thesis"],"thesis:degree_name":["Molecular Microbiology and Immunology"],"thesis:institution_name":["University of Nevada, Reno"]},"updated_at":"2026-07-27T21:45:34Z"}