{"id":{"repo_id":"unr","oai_identifier":"oai:scholarwolf.unr.edu:11714/3112"},"canonical_url":"https://search.dev.ndltd.org/etd/unr/oai:scholarwolf.unr.edu:11714/3112","repository":{"repo_id":"unr","name":"University of Nevada - Reno","base_url":"https://scholarwolf.unr.edu/server/oai/request"},"display":{"title":"Collective Force Generator Model of Muscle Contraction: Theoretical and Experimental Support for Factors Beyond Detachment Kinetics that Influence Unloaded Shortening Velocities of Muscle","abstract":"This dissertation covers three related approaches to developing a more complete understanding of how single molecule properties of muscle myosin collectively generate unloaded shortening velocities, V. Theory, experimentation, and simulation results all contributed to answering fundamental muscle research questions. These questions focused on addressing how single myosin molecule properties scale in an ensemble to collectively perform work that results in V and how attachment kinetics affect V. Our work has resulted in the development of a model, based on quantifiable kinetic and physical parameters of myosin and actin, which provides a set of mechanisms to describe experimental data that the predominate models of muscle contraction are unable to.","abstract_html":"This dissertation covers three related approaches to developing a more complete understanding of how single molecule properties of muscle myosin collectively generate unloaded shortening velocities, V. Theory, experimentation, and simulation results all contributed to answering fundamental muscle research questions. These questions focused on addressing how single myosin molecule properties scale in an ensemble to collectively perform work that results in V and how attachment kinetics affect V. Our work has resulted in the development of a model, based on quantifiable kinetic and physical parameters of myosin and actin, which provides a set of mechanisms to describe experimental data that the predominate models of muscle contraction are unable to.","abstract_has_math":false,"creators":["Jackson, Del R."],"institution":null,"degree_name":null,"degree_level":"Doctorate Degree","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Baker, Jonathan E."],"committee_chairs":[],"committee_members":["Cremo, Christine","Harris, Frederick C.","Publicover, Nelson G.","Schlauch, Karen"],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-27T21:47:03Z","subjects":["actin","force","kinetics","model","muscle","myosin"],"languages":[],"rights":["In Copyright(All Rights Reserved)"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11714/3112","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Baker, Jonathan E."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Cremo, Christine","Harris, Frederick C.","Publicover, Nelson G.","Schlauch, Karen"]},{"key":"dc:creator","label":"Author","values":["Jackson, Del R."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-01T12:28:32Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-01T12:28:32Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctorate Degree"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["actin","force","kinetics","model","muscle","myosin"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright(All Rights Reserved)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11714/3112"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This dissertation covers three related approaches to developing a more complete understanding of how single molecule properties of muscle myosin collectively generate unloaded shortening velocities, V. Theory, experimentation, and simulation results all contributed to answering fundamental muscle research questions. These questions focused on addressing how single myosin molecule properties scale in an ensemble to collectively perform work that results in V and how attachment kinetics affect V. Our work has resulted in the development of a model, based on quantifiable kinetic and physical parameters of myosin and actin, which provides a set of mechanisms to describe experimental data that the predominate models of muscle contraction are unable to."]},{"key":"dc:format","label":"Dc Format","values":["PDF"]},{"key":"dc:title","label":"Title","values":["Collective Force Generator Model of Muscle Contraction: Theoretical and Experimental Support for Factors Beyond Detachment Kinetics that Influence Unloaded Shortening Velocities of Muscle"]}]}],"canonical_facts":{"dc:contributor.advisor":["Baker, Jonathan E."],"dc:contributor.committeemember":["Cremo, Christine","Harris, Frederick C.","Publicover, Nelson G.","Schlauch, Karen"],"dc:creator":["Jackson, Del R."],"dc:date.accessioned":["2018-05-01T12:28:32Z"],"dc:date.available":["2018-05-01T12:28:32Z"],"dc:date.issued":["2013"],"dc:description.abstract":["This dissertation covers three related approaches to developing a more complete understanding of how single molecule properties of muscle myosin collectively generate unloaded shortening velocities, V. Theory, experimentation, and simulation results all contributed to answering fundamental muscle research questions. These questions focused on addressing how single myosin molecule properties scale in an ensemble to collectively perform work that results in V and how attachment kinetics affect V. Our work has resulted in the development of a model, based on quantifiable kinetic and physical parameters of myosin and actin, which provides a set of mechanisms to describe experimental data that the predominate models of muscle contraction are unable to."],"dc:format":["PDF"],"dc:identifier.uri":["http://hdl.handle.net/11714/3112"],"dc:rights":["In Copyright(All Rights Reserved)"],"dc:subject":["actin","force","kinetics","model","muscle","myosin"],"dc:title":["Collective Force Generator Model of Muscle Contraction: Theoretical and Experimental Support for Factors Beyond Detachment Kinetics that Influence Unloaded Shortening Velocities of Muscle"],"dc:type":["Dissertation"],"thesis:degree_level":["Doctorate Degree"]},"updated_at":"2026-07-27T21:47:03Z"}