Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids

Our project was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole esters, a series of 4,5-diaryl-1-substituted-1,2,3-triazole analogues and a series of 4,5- diaryl-2-substituted-1,2,3-triazoles. Our research group has been interested in the synthesis of amphibian alkaloids due to their interesting biological activities. We have recently developed a general synthetic strategy which can rapidly prepare a few amphibian alkaloids simply from the abundant natural product (-)- cocaine This strategy was first successfully applied to the synthesis of (-)-monomorine. More recently, this strategy has also been utilized in the syntheses of both of the enantiomers of cispyrrolidine 225H and (+)-gephyrotoxin 287C.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Year

2009

Author dc:creator

• Shu, Hong

Contributors dc:contributor

• Trudell, Mark
• Jursic, Branko S.
• Wang, Guijun

• endocannabinoid system
• CB1 receptors
• antagonists
• drug abuse
• binding affinity
• amphibian alkaloid
• formal synthesis
• neuronal nicotinic acetylcholine receptor

Repository record dc:identifier

https://scholarworks.uno.edu/td/1104

OAI identifier oai:identifier

oai:scholarworks.uno.edu:td-2085