{"id":{"repo_id":"uno","oai_identifier":"oai:scholarworks.uno.edu:td-1425"},"canonical_url":"https://search.dev.ndltd.org/etd/uno/oai:scholarworks.uno.edu:td-1425","repository":{"repo_id":"uno","name":"University of New Orleans","base_url":"https://scholarworks.uno.edu/do/oai/"},"display":{"title":"Comparing the Effects of Various Estrogen Replacement Paradigms on Working Memory Performance in the Radial-Arm Maze","abstract":"The current study compared the impact of different paradigms of estradiol replacement on working memory performance. In adult ovariectomized rats, a vehicle-treated control group (n=10) was compared to three estradiol replacement paradigms: 1) continuous delivery via Silastic capsules (n=8); 2) cyclic replacement via two 10 ìg injections on two out of every four days (n=10); 3) cyclic replacement via one 2 ìg injection every four days (n=10). While treatment continued, animals were tested over 24 days in the 8-arm radial maze. After this acquisition period, various delay times were introduced between 4th and 5th arm choices. Treatments had no effects during acquisition or delay trials of 1 min, 10 min, and 3 hours. However, when a 5-hour delay was imposed, rats receiving estradiol via implants outperformed all other groups. These results indicate that long-term continuous estradiol replacement is more effective in enhancing working memory performance than the tested cyclic paradigms.","abstract_html":"The current study compared the impact of different paradigms of estradiol replacement on working memory performance. In adult ovariectomized rats, a vehicle-treated control group (n=10) was compared to three estradiol replacement paradigms: 1) continuous delivery via Silastic capsules (n=8); 2) cyclic replacement via two 10 ìg injections on two out of every four days (n=10); 3) cyclic replacement via one 2 ìg injection every four days (n=10). While treatment continued, animals were tested over 24 days in the 8-arm radial maze. After this acquisition period, various delay times were introduced between 4th and 5th arm choices. Treatments had no effects during acquisition or delay trials of 1 min, 10 min, and 3 hours. However, when a 5-hour delay was imposed, rats receiving estradiol via implants outperformed all other groups. These results indicate that long-term continuous estradiol replacement is more effective in enhancing working memory performance than the tested cyclic paradigms.","abstract_has_math":false,"creators":["Bohacek, Johannes"],"institution":null,"degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Daniel, Jill","La Hoste, Gerald","King, Bruce M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-08-09T07:00:00Z","date_published":"2006-08-09T07:00:00Z","updated_at":"2026-07-24T05:28:16Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarworks.uno.edu/td/404","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Daniel, Jill","La Hoste, Gerald","King, Bruce M."]},{"key":"dc:creator","label":"Author","values":["Bohacek, Johannes"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarworks.uno.edu/td/404"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The current study compared the impact of different paradigms of estradiol replacement on working memory performance. In adult ovariectomized rats, a vehicle-treated control group (n=10) was compared to three estradiol replacement paradigms: 1) continuous delivery via Silastic capsules (n=8); 2) cyclic replacement via two 10 ìg injections on two out of every four days (n=10); 3) cyclic replacement via one 2 ìg injection every four days (n=10). While treatment continued, animals were tested over 24 days in the 8-arm radial maze. After this acquisition period, various delay times were introduced between 4th and 5th arm choices. Treatments had no effects during acquisition or delay trials of 1 min, 10 min, and 3 hours. However, when a 5-hour delay was imposed, rats receiving estradiol via implants outperformed all other groups. These results indicate that long-term continuous estradiol replacement is more effective in enhancing working memory performance than the tested cyclic paradigms."]},{"key":"dc:title","label":"Title","values":["Comparing the Effects of Various Estrogen Replacement Paradigms on Working Memory Performance in the Radial-Arm Maze"]}]}],"canonical_facts":{"dc:contributor":["Daniel, Jill","La Hoste, Gerald","King, Bruce M."],"dc:creator":["Bohacek, Johannes"],"dc:description.abstract":["The current study compared the impact of different paradigms of estradiol replacement on working memory performance. In adult ovariectomized rats, a vehicle-treated control group (n=10) was compared to three estradiol replacement paradigms: 1) continuous delivery via Silastic capsules (n=8); 2) cyclic replacement via two 10 ìg injections on two out of every four days (n=10); 3) cyclic replacement via one 2 ìg injection every four days (n=10). While treatment continued, animals were tested over 24 days in the 8-arm radial maze. After this acquisition period, various delay times were introduced between 4th and 5th arm choices. Treatments had no effects during acquisition or delay trials of 1 min, 10 min, and 3 hours. However, when a 5-hour delay was imposed, rats receiving estradiol via implants outperformed all other groups. These results indicate that long-term continuous estradiol replacement is more effective in enhancing working memory performance than the tested cyclic paradigms."],"dc:identifier":["https://scholarworks.uno.edu/td/404"],"dc:title":["Comparing the Effects of Various Estrogen Replacement Paradigms on Working Memory Performance in the Radial-Arm Maze"],"thesis:degree_discipline":["Psychology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."]},"updated_at":"2026-07-24T05:28:16Z"}