{"id":{"repo_id":"unm","oai_identifier":"oai:digitalrepository.unm.edu:nsms_etds-1013"},"canonical_url":"https://search.dev.ndltd.org/etd/unm/oai:digitalrepository.unm.edu:nsms_etds-1013","repository":{"repo_id":"unm","name":"University of New Mexico","base_url":"https://digitalrepository.unm.edu/do/oai/"},"display":{"title":"Structural Influences on the Photochemistry and Photophysical Properties of p-Phenylene Ethynylenes: Aggregation Effects and Solvent Interactions","abstract":"Compounds based on the p-phenylene ethynylene backbone with pendant charged groups, known as conjugated polyelectrolytes, have been of particular interest in recent years due to their solubility in water, sensing properties, and biocidal activity against bacteria, viruses, and fungi. A series of oligomers based on these polymers were synthesized (OPEs), and several interesting questions about their photophysical and biocidal properties were raised by earlier experimental observations, which are addressed by this dissertation. The study initially focuses on the influence of the backbone length and presence of carboxyester substituents on the photophysical properties of the OPEs. Next, the photochemistry of the OPEs is explored as the products and mechanisms are elucidated through isotopic studies with mass spectrometry, revealing that photo-protonation by water and addition of oxygen across the triple bond are the two dominant initial mechanisms of all major pathways in aqueous solution. Finally, the aggregation of OPEs with is studied in two systems: surfactants and model bacterial membranes. The placement of the ionic alkyl substituents played a dominant role in determining the outcome of molecular interactions and type of aggregates which resulted between OPEs and both systems. Biophysical simulations of the interactions between OPEs and these two systems provided mechanistic insight into the mechanism of bacterial membrane disruption and the attenuation of photodegradation observed with OPE-surfactant complexes. In addition to determining the OPEs could be protected from photolysis and the structural basis for aggregate type, surfactant complexation was used to form a biocidal complex from a non-biocidal anionic OPE. The work presented will be of great use for future developments in sensors, biocides, photo-resistant materials, and drug delivery applications.","abstract_html":"Compounds based on the p-phenylene ethynylene backbone with pendant charged groups, known as conjugated polyelectrolytes, have been of particular interest in recent years due to their solubility in water, sensing properties, and biocidal activity against bacteria, viruses, and fungi. A series of oligomers based on these polymers were synthesized (OPEs), and several interesting questions about their photophysical and biocidal properties were raised by earlier experimental observations, which are addressed by this dissertation. The study initially focuses on the influence of the backbone length and presence of carboxyester substituents on the photophysical properties of the OPEs. Next, the photochemistry of the OPEs is explored as the products and mechanisms are elucidated through isotopic studies with mass spectrometry, revealing that photo-protonation by water and addition of oxygen across the triple bond are the two dominant initial mechanisms of all major pathways in aqueous solution. Finally, the aggregation of OPEs with is studied in two systems: surfactants and model bacterial membranes. The placement of the ionic alkyl substituents played a dominant role in determining the outcome of molecular interactions and type of aggregates which resulted between OPEs and both systems. Biophysical simulations of the interactions between OPEs and these two systems provided mechanistic insight into the mechanism of bacterial membrane disruption and the attenuation of photodegradation observed with OPE-surfactant complexes. In addition to determining the OPEs could be protected from photolysis and the structural basis for aggregate type, surfactant complexation was used to form a biocidal complex from a non-biocidal anionic OPE. The work presented will be of great use for future developments in sensors, biocides, photo-resistant materials, and drug delivery applications.","abstract_has_math":false,"creators":["Hill, Eric Harris"],"institution":null,"degree_name":"Nanoscience and Microsystems","degree_level":"Dissertation","degree_discipline":"Nanoscience and Microsystems","degree_department":null,"school":null,"contributors":["Whitten, David G.","Deborah, Evans G.","Schanze, Kirk S.","Shreve, Andrew P."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-01-28T08:00:00Z","date_published":"2015-01-28T08:00:00Z","updated_at":"2026-07-24T05:26:42Z","subjects":["Antimicrobial","Cell Membranes","Colloids","Molecular Dynamics","Sensors","Surfactants"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalrepository.unm.edu/nsms_etds/14"],"render_values":[{"text":"https://digitalrepository.unm.edu/nsms_etds/14","href":"https://digitalrepository.unm.edu/nsms_etds/14","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/1928/25781","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Whitten, David G.","Deborah, Evans G.","Schanze, Kirk S.","Shreve, Andrew P."]},{"key":"dc:creator","label":"Author","values":["Hill, Eric Harris"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Nanoscience and Microsystems"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation","Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Nanoscience and Microsystems"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Antimicrobial","Cell Membranes","Colloids","Molecular Dynamics","Sensors","Surfactants"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/1928/25781","https://digitalrepository.unm.edu/nsms_etds/14"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Compounds based on the p-phenylene ethynylene backbone with pendant charged groups, known as conjugated polyelectrolytes, have been of particular interest in recent years due to their solubility in water, sensing properties, and biocidal activity against bacteria, viruses, and fungi. A series of oligomers based on these polymers were synthesized (OPEs), and several interesting questions about their photophysical and biocidal properties were raised by earlier experimental observations, which are addressed by this dissertation. The study initially focuses on the influence of the backbone length and presence of carboxyester substituents on the photophysical properties of the OPEs. Next, the photochemistry of the OPEs is explored as the products and mechanisms are elucidated through isotopic studies with mass spectrometry, revealing that photo-protonation by water and addition of oxygen across the triple bond are the two dominant initial mechanisms of all major pathways in aqueous solution. Finally, the aggregation of OPEs with is studied in two systems: surfactants and model bacterial membranes. The placement of the ionic alkyl substituents played a dominant role in determining the outcome of molecular interactions and type of aggregates which resulted between OPEs and both systems. Biophysical simulations of the interactions between OPEs and these two systems provided mechanistic insight into the mechanism of bacterial membrane disruption and the attenuation of photodegradation observed with OPE-surfactant complexes. In addition to determining the OPEs could be protected from photolysis and the structural basis for aggregate type, surfactant complexation was used to form a biocidal complex from a non-biocidal anionic OPE. The work presented will be of great use for future developments in sensors, biocides, photo-resistant materials, and drug delivery applications."]},{"key":"dc:title","label":"Title","values":["Structural Influences on the Photochemistry and Photophysical Properties of p-Phenylene Ethynylenes: Aggregation Effects and Solvent Interactions"]}]}],"canonical_facts":{"dc:contributor":["Whitten, David G.","Deborah, Evans G.","Schanze, Kirk S.","Shreve, Andrew P."],"dc:creator":["Hill, Eric Harris"],"dc:description.abstract":["Compounds based on the p-phenylene ethynylene backbone with pendant charged groups, known as conjugated polyelectrolytes, have been of particular interest in recent years due to their solubility in water, sensing properties, and biocidal activity against bacteria, viruses, and fungi. A series of oligomers based on these polymers were synthesized (OPEs), and several interesting questions about their photophysical and biocidal properties were raised by earlier experimental observations, which are addressed by this dissertation. The study initially focuses on the influence of the backbone length and presence of carboxyester substituents on the photophysical properties of the OPEs. Next, the photochemistry of the OPEs is explored as the products and mechanisms are elucidated through isotopic studies with mass spectrometry, revealing that photo-protonation by water and addition of oxygen across the triple bond are the two dominant initial mechanisms of all major pathways in aqueous solution. Finally, the aggregation of OPEs with is studied in two systems: surfactants and model bacterial membranes. The placement of the ionic alkyl substituents played a dominant role in determining the outcome of molecular interactions and type of aggregates which resulted between OPEs and both systems. Biophysical simulations of the interactions between OPEs and these two systems provided mechanistic insight into the mechanism of bacterial membrane disruption and the attenuation of photodegradation observed with OPE-surfactant complexes. In addition to determining the OPEs could be protected from photolysis and the structural basis for aggregate type, surfactant complexation was used to form a biocidal complex from a non-biocidal anionic OPE. The work presented will be of great use for future developments in sensors, biocides, photo-resistant materials, and drug delivery applications."],"dc:identifier":["http://hdl.handle.net/1928/25781","https://digitalrepository.unm.edu/nsms_etds/14"],"dc:language":["English"],"dc:subject":["Antimicrobial","Cell Membranes","Colloids","Molecular Dynamics","Sensors","Surfactants"],"dc:title":["Structural Influences on the Photochemistry and Photophysical Properties of p-Phenylene Ethynylenes: Aggregation Effects and Solvent Interactions"],"thesis:degree_discipline":["Nanoscience and Microsystems"],"thesis:degree_level":["Dissertation","Doctoral"],"thesis:degree_name":["Nanoscience and Microsystems"]},"updated_at":"2026-07-24T05:26:42Z"}