Hybrid System Identification of Manual Tracking Submovements in Parkinson's Disease

Seemingly smooth motions in manual tracking, (e.g., following a moving target with a joystick input) are actually sequences of submovements: short, open-loop motions that have been previously learned. In Parkinson's disease, a neurodegenerative movement disorder, characterizations of motor performance can yield insight into underlying neurological mechanisms and therefore into potential treatment strategies. We focus on characterizing submovements through Hybrid System Identification, in which the dynamics of each submovement, the mode sequence and timing, and switching mechanisms are all unknown. We describe an initialization that provides a mode sequence and estimate of the dynamics of submovements, then apply hybrid optimization techniques based on embedding to solve a constrained nonlinear program. We also use the existing geometric approach for hybrid system identification to analyze our model and explain the deficits and advantages of each. These methods are applied to data gathered from subjects with Parkinson's disease (on and off L-dopa medication) and from age-matched control subjects, and the results compared across groups demonstrating robust differences. Lastly, we develop a scheme to estimate the switching mechanism of the modeled hybrid system by using the principle of maximum margin separating hyperplane, which is a convex optimization problem, over the affine parameters describing the switching surface and provide a means o characterizing when too many or too few parameters are hypothesized to lie in the switching surface.

Name thesis:degree_name

Electrical Engineering

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Electrical and Computer Engineering

Year

2016

Author dc:creator

• Gonzalez, Carlos

Contributors dc:contributor

• Oishi, Meeko
• Fierro, Rafael
• Abdallah, Chaouki

• Hybrid system identification
• Embedded Optimization
• Parkinson's Disease
• Submovements
• Manual Tracking

Language dc:language

English

Repository record dc:identifier

https://digitalrepository.unm.edu/ece_etds/101

OAI identifier oai:identifier

oai:digitalrepository.unm.edu:ece_etds-1100