{"id":{"repo_id":"unlv","oai_identifier":"oai:oasis.library.unlv.edu:rtds-2587"},"canonical_url":"https://search.dev.ndltd.org/etd/unlv/oai:oasis.library.unlv.edu:rtds-2587","repository":{"repo_id":"unlv","name":"University of Nevada - Las Vegas","base_url":"https://oasis.library.unlv.edu/do/oai/"},"display":{"title":"Effects of blood vessel permeability on mechanical properties of bone under micro-gravity conditions","abstract":"Loss of bone mass is one important physiological change observed in astronauts after medium and long-term exposure to microgravity conditions. The objective of the current study is to test the hypothesis that loss of bone mass under microgravity can be inhibited if the same micro-force distribution under earth gravity (body weight) is achieved by increasing the blood vessel permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the hypothesis by examining the bone mechanical properties (Young's modulus) of rat femur and humerus for four groups of animals. (i) control, (ii) exposure to a bio-frequency spectrum (BFS) light, (iii) tail-suspension (simulating microgravity condition), and (iv) tail-suspension and exposure to a bio-frequency spectrum (BFS) light. Twenty-eight adult rats of ∼250 g were used and kept for 50 days before sacrificing. The average Young's moduli for each group of rat femurs are (i) 1.78 GPa, (ii) 2.04 GPa, (iii) 2.03 GPa.","abstract_html":"Loss of bone mass is one important physiological change observed in astronauts after medium and long-term exposure to microgravity conditions. The objective of the current study is to test the hypothesis that loss of bone mass under microgravity can be inhibited if the same micro-force distribution under earth gravity (body weight) is achieved by increasing the blood vessel permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the hypothesis by examining the bone mechanical properties (Young's modulus) of rat femur and humerus for four groups of animals. (i) control, (ii) exposure to a bio-frequency spectrum (BFS) light, (iii) tail-suspension (simulating microgravity condition), and (iv) tail-suspension and exposure to a bio-frequency spectrum (BFS) light. Twenty-eight adult rats of ∼250 g were used and kept for 50 days before sacrificing. The average Young's moduli for each group of rat femurs are (i) 1.78 GPa, (ii) 2.04 GPa, (iii) 2.03 GPa.","abstract_has_math":false,"creators":["Drollinger, Robert L"],"institution":"University of Nevada, Las Vegas","degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Bingmei Fu"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2003,"date_issued":"2003-01-01T08:00:00Z","date_published":"2003-01-01T08:00:00Z","updated_at":"2026-07-24T05:25:40Z","subjects":[],"languages":["English"],"rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://oasis.library.unlv.edu/rtds/1588"],"render_values":[{"text":"https://oasis.library.unlv.edu/rtds/1588","href":"https://oasis.library.unlv.edu/rtds/1588","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25669/mmf9-y27u","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bingmei Fu"]},{"key":"dc:creator","label":"Author","values":["Drollinger, Robert L"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["University of Nevada, Las Vegas"]},{"key":"dc:type","label":"Dc Type","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25669/mmf9-y27u","https://oasis.library.unlv.edu/rtds/1588","https://oasis.library.unlv.edu/context/rtds/article/2587/viewcontent/uc.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Loss of bone mass is one important physiological change observed in astronauts after medium and long-term exposure to microgravity conditions. The objective of the current study is to test the hypothesis that loss of bone mass under microgravity can be inhibited if the same micro-force distribution under earth gravity (body weight) is achieved by increasing the blood vessel permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the hypothesis by examining the bone mechanical properties (Young's modulus) of rat femur and humerus for four groups of animals. (i) control, (ii) exposure to a bio-frequency spectrum (BFS) light, (iii) tail-suspension (simulating microgravity condition), and (iv) tail-suspension and exposure to a bio-frequency spectrum (BFS) light. Twenty-eight adult rats of ∼250 g were used and kept for 50 days before sacrificing. The average Young's moduli for each group of rat femurs are (i) 1.78 GPa, (ii) 2.04 GPa, (iii) 2.03 GPa."]},{"key":"dc:format","label":"Dc Format","values":["pdf"]},{"key":"dc:title","label":"Title","values":["Effects of blood vessel permeability on mechanical properties of bone under micro-gravity conditions"]}]}],"canonical_facts":{"dc:contributor":["Bingmei Fu"],"dc:creator":["Drollinger, Robert L"],"dc:description.abstract":["Loss of bone mass is one important physiological change observed in astronauts after medium and long-term exposure to microgravity conditions. The objective of the current study is to test the hypothesis that loss of bone mass under microgravity can be inhibited if the same micro-force distribution under earth gravity (body weight) is achieved by increasing the blood vessel permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the hypothesis by examining the bone mechanical properties (Young's modulus) of rat femur and humerus for four groups of animals. (i) control, (ii) exposure to a bio-frequency spectrum (BFS) light, (iii) tail-suspension (simulating microgravity condition), and (iv) tail-suspension and exposure to a bio-frequency spectrum (BFS) light. Twenty-eight adult rats of ∼250 g were used and kept for 50 days before sacrificing. The average Young's moduli for each group of rat femurs are (i) 1.78 GPa, (ii) 2.04 GPa, (iii) 2.03 GPa."],"dc:format":["pdf"],"dc:identifier":["10.25669/mmf9-y27u","https://oasis.library.unlv.edu/rtds/1588","https://oasis.library.unlv.edu/context/rtds/article/2587/viewcontent/uc.pdf"],"dc:language":["English"],"dc:publisher":["University of Nevada, Las Vegas"],"dc:rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["Effects of blood vessel permeability on mechanical properties of bone under micro-gravity conditions"],"dc:type":["Text"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T05:25:40Z"}