{"id":{"repo_id":"unlv","oai_identifier":"oai:oasis.library.unlv.edu:rtds-2484"},"canonical_url":"https://search.dev.ndltd.org/etd/unlv/oai:oasis.library.unlv.edu:rtds-2484","repository":{"repo_id":"unlv","name":"University of Nevada - Las Vegas","base_url":"https://oasis.library.unlv.edu/do/oai/"},"display":{"title":"Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders","abstract":"The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin (SRIF) is a small, inhibitory neuropeptide present throughout the CNS. Because SRIF is an inhibitory neuropeptide we sought to determine the effects of SRIF on the production of IL-6 in rat C6 glial tumor cells. The release of IL-6 in the C6 cell conditioned media was quantified using the IL-6 dependent 7TD1 hybridoma bioassay; We decided to investigate GABA ability to inhibit the release of IL-6 by IL-1beta; To better understand the signal pathways of IL-1beta that results in the release of IL-6 we used the inhibitors SP600125 and SB203580. SB203580 is a p38 MAPK inhibitor that targets the p38alpha and p38beta2 kinases, while the p38beta kinase exhibits only partially sensitivity. The inhibitor SP600125 targets the JNK kinase. (Abstract shortened by UMI.).","abstract_html":"The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin (SRIF) is a small, inhibitory neuropeptide present throughout the CNS. Because SRIF is an inhibitory neuropeptide we sought to determine the effects of SRIF on the production of IL-6 in rat C6 glial tumor cells. The release of IL-6 in the C6 cell conditioned media was quantified using the IL-6 dependent 7TD1 hybridoma bioassay; We decided to investigate GABA ability to inhibit the release of IL-6 by IL-1beta; To better understand the signal pathways of IL-1beta that results in the release of IL-6 we used the inhibitors SP600125 and SB203580. SB203580 is a p38 MAPK inhibitor that targets the p38alpha and p38beta2 kinases, while the p38beta kinase exhibits only partially sensitivity. The inhibitor SP600125 targets the JNK kinase. (Abstract shortened by UMI.).","abstract_has_math":false,"creators":["Horrell, Donald Scott"],"institution":"University of Nevada, Las Vegas","degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Bryan L. Spangelo"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002-01-01T08:00:00Z","date_published":"2002-01-01T08:00:00Z","updated_at":"2026-07-24T05:25:33Z","subjects":[],"languages":["English"],"rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://oasis.library.unlv.edu/rtds/1485"],"render_values":[{"text":"https://oasis.library.unlv.edu/rtds/1485","href":"https://oasis.library.unlv.edu/rtds/1485","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25669/pe3a-dy5y","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bryan L. Spangelo"]},{"key":"dc:creator","label":"Author","values":["Horrell, Donald Scott"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["University of Nevada, Las Vegas"]},{"key":"dc:type","label":"Dc Type","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25669/pe3a-dy5y","https://oasis.library.unlv.edu/rtds/1485","https://oasis.library.unlv.edu/context/rtds/article/2484/viewcontent/uc.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin (SRIF) is a small, inhibitory neuropeptide present throughout the CNS. Because SRIF is an inhibitory neuropeptide we sought to determine the effects of SRIF on the production of IL-6 in rat C6 glial tumor cells. The release of IL-6 in the C6 cell conditioned media was quantified using the IL-6 dependent 7TD1 hybridoma bioassay; We decided to investigate GABA ability to inhibit the release of IL-6 by IL-1beta; To better understand the signal pathways of IL-1beta that results in the release of IL-6 we used the inhibitors SP600125 and SB203580. SB203580 is a p38 MAPK inhibitor that targets the p38alpha and p38beta2 kinases, while the p38beta kinase exhibits only partially sensitivity. The inhibitor SP600125 targets the JNK kinase. (Abstract shortened by UMI.)."]},{"key":"dc:format","label":"Dc Format","values":["pdf"]},{"key":"dc:title","label":"Title","values":["Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders"]}]}],"canonical_facts":{"dc:contributor":["Bryan L. Spangelo"],"dc:creator":["Horrell, Donald Scott"],"dc:description.abstract":["The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin (SRIF) is a small, inhibitory neuropeptide present throughout the CNS. Because SRIF is an inhibitory neuropeptide we sought to determine the effects of SRIF on the production of IL-6 in rat C6 glial tumor cells. The release of IL-6 in the C6 cell conditioned media was quantified using the IL-6 dependent 7TD1 hybridoma bioassay; We decided to investigate GABA ability to inhibit the release of IL-6 by IL-1beta; To better understand the signal pathways of IL-1beta that results in the release of IL-6 we used the inhibitors SP600125 and SB203580. SB203580 is a p38 MAPK inhibitor that targets the p38alpha and p38beta2 kinases, while the p38beta kinase exhibits only partially sensitivity. The inhibitor SP600125 targets the JNK kinase. (Abstract shortened by UMI.)."],"dc:format":["pdf"],"dc:identifier":["10.25669/pe3a-dy5y","https://oasis.library.unlv.edu/rtds/1485","https://oasis.library.unlv.edu/context/rtds/article/2484/viewcontent/uc.pdf"],"dc:language":["English"],"dc:publisher":["University of Nevada, Las Vegas"],"dc:rights":["IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders"],"dc:type":["Text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T05:25:33Z"}