Characterization of the pleiotropic effects of the Drosophila gene mushroom body miniature B

The mushroom body miniature B ( mbmB) mutation has documented defects in adult mushroom body anatomy, olfactory memory and female fertility. In this thesis I report that mbmB mutants also have reduced viability and growth rate. I further demonstrate, using the mushroom body cell marker dachshund, that loss of mbmB function does not affect the early development of mushroom body neuroectoderm and neuroblasts. Additionally, I found the observed delay in growth and reduced viability were not manifested during embryonic development; Courtship behavior assays and immunohistochemical techniques were used to investigate causes of mbmB female sterility. Courtship involving mbmB females is delayed and reduced in total amount relative to that of wild type. Additional data presented herein suggest that mechanisms required during early oogenesis are not significantly impaired by loss of mbmB function. However, evidence is presented which demonstrates abnormalities in follicle-cell migration in mbmB mutants.

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biological Science

Grantor dc:publisher

University of Nevada, Las Vegas

Year

2001

Author dc:creator

• Ginsburg, Michael Louis

Contributors dc:contributor

• J. Steven de Belle

Statement dc:rights

• IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Language dc:language

English

Identifier

https://oasis.library.unlv.edu/rtds/1362

OAI identifier oai:identifier

oai:oasis.library.unlv.edu:rtds-2361