Mathematical models for interendothelial cleft

Vascular endothelium is the principal barrier to, and regulator of, material exchange between circulating blood and the body tissues. Based on previous research in this field, two new theoretical models have been developed in this thesis. One is to investigate structural mechanisms in the regulation of microvessel permeability by cAMP. The other is to examine the charge effects of surface glycocalyx on microvessel permeability; To investigate the microstructural mechanisms of decreasing microvascular permeability induced by the enhancement of intraendothelial adenosine 3 ',5'-cyclic monophosphate (CAMP) levels, we extended the previous analytical model developed by Fu et al. (1994) for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance; Previous experimental studies revealed that the endothelial surface glycocalyx might carry negative charges. To investigate this charge effect on microvessel permeability, we extended the three-dimensional (3-D) junction-orifice-fiber matrix model developed by Fu et al. (1994) for the interendothelial cleft to include a negatively charged glycocalyx layer at the entrance of the interendothelial cleft. (Abstract shortened by UMI.).

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Mechanical Engineering

Grantor dc:publisher

University of Nevada, Las Vegas

Year

2001

Author dc:creator

• Chen, Bin

Contributors dc:contributor

• Bingmei Fu

Statement dc:rights

• IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Language dc:language

English

Identifier

https://oasis.library.unlv.edu/rtds/1316

OAI identifier oai:identifier

oai:oasis.library.unlv.edu:rtds-2315